Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter
文献类型：期刊论文
| 作者 | Li, Mofei3,4,5 ; Wu, Meng1,2,4,5; Sun, Yuanyuan2,4,5; Sun, Li1,2,4,5
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| 刊名 | COMMUNICATIONS BIOLOGY
 |
| 出版日期 | 2022-06-29 |
| 卷号 | 5期号:1页码:13 |
| DOI | 10.1038/s42003-022-03587-3 |
| 通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Edwardsiella tarda TraT promotes cellular infection and serves as an anti-complement factor, shedding light on the mechanisms of E. tarda's strong evasion of killing by the host. Edwardsiella tarda is a well-known bacterial pathogen with a broad range of host, including fish, amphibians, and mammals. One eminent virulence feature of E. tarda is its strong ability to resist the killing of host serum complement, but the involving mechanism is unclear. In this report, we identified E. tarda TraT as a key player in both complement resistance and cellular invasion. TraT, a surface-localized protein, bound and recruited complement factor H onto E. tarda, whereby inhibiting complement activation via the alternative pathway. TraT also interacted with host CD46 in a specific complement control protein domain-dependent manner, whereby facilitating the cellular infection and tissue dissemination of E. tarda. Thus, by acting as an anti-complement factor and a cellular infection promoter, TraT makes an important contribution to the complement evasion and systemic infection of E. tarda. These results add insights into the pathogen-host interaction mechanism during E. tarda infection. |
| 资助项目 | National Key Research and Development Program of China[2018YFD0900500] ; National Natural Science Foundation of China[31972831] ; National Natural Science Foundation of China[41906108] ; Young Scholar Program of Tianjin Distinguished Professor ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PORTFOLIO |
| WOS记录号 | WOS:000820414000008 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/179595]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Li |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Tianjin Normal Univ, Coll Life Sci, Tianjin Key Lab Anim & Plant Resistance, 393 West Binshui Rd, Tianjin 300387, Peoples R China 4.Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Inst Oceanol, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mofei,Wu, Meng,Sun, Yuanyuan,et al. Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter[J]. COMMUNICATIONS BIOLOGY,2022,5(1):13. |
| APA | Li, Mofei,Wu, Meng,Sun, Yuanyuan,&Sun, Li.(2022).Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter.COMMUNICATIONS BIOLOGY,5(1),13. |
| MLA | Li, Mofei,et al."Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter".COMMUNICATIONS BIOLOGY 5.1(2022):13. |
入库方式： OAI收割
来源：海洋研究所
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