Acute brain vascular regeneration occurs via lymphatic transdifferentiation
文献类型：期刊论文
| 作者 | Chen, Jingying1,2; Li, Xiuhua2; Ni, Rui2; Chen, Qi2; Yang, Qifen2; He, Jianbo2; Luo, Lingfei1,2 |
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2021-11-22 |
| 卷号 | 56期号:22页码:3115-+ |
| ISSN号 | 1534-5807 |
| DOI | 10.1016/j.devcel.2021.09.005 |
| 通讯作者 | Luo, Lingfei(lluo@swu.edu.cn) |
| 英文摘要 | Acute ischemic stroke damages the regional brain blood vessel (BV) network. Acute recovery of basic blood flows, which is carried out by the earliest regenerated BVs, are critical to improve clinical outcomes and minimize lethality. Although the late-regenerated BVs form via growing along the meninge-derived ingrown lymphatic vessels (iLVs), mechanisms underlying the early, acute BV regeneration remain elusive. Using zebrafish cerebrovascular injury models, we show that the earliest regenerated BVs come from lymphatic trans differentiation, a hitherto unappreciated process in vertebrates. Mechanistically, the LV-to-BV transdifferentiation occurs exclusively in the stand-alone iLVs through Notch activation. In the track iLVs adhered by late regenerated BVs, transdifferentiation never occurs because the BV-expressing EphrinB2a paracellularly activates the iLV-expressing EphB4a to inhibit Notch activation. Suppression of LV-to-BV transdifferentiation blocks acute BV regeneration and becomes lethal. These results demonstrate that acute BV regeneration occurs via lymphatic transdifferentiation, suggesting this process and key regulatory molecules EphrinB2a/ EphB4a/Notch as new postischemic therapeutic targets. |
| 资助项目 | National Natural Science Foundation of China[31730060] ; National Natural Science Foundation of China[32000576] ; Natural Science Foundation of Chongqing[cstc2020jcyj-msxmX0882] ; 111 Program[B14037] |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000730205700001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/14704]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Luo, Lingfei |
| 作者单位 | 1.Univ Chinese Acad Sci Chongqing, Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Southwest Univ, Inst Dev Biol & Regenerat Med, Chongqing 400715, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jingying,Li, Xiuhua,Ni, Rui,et al. Acute brain vascular regeneration occurs via lymphatic transdifferentiation[J]. DEVELOPMENTAL CELL,2021,56(22):3115-+. |
| APA | Chen, Jingying.,Li, Xiuhua.,Ni, Rui.,Chen, Qi.,Yang, Qifen.,...&Luo, Lingfei.(2021).Acute brain vascular regeneration occurs via lymphatic transdifferentiation.DEVELOPMENTAL CELL,56(22),3115-+. |
| MLA | Chen, Jingying,et al."Acute brain vascular regeneration occurs via lymphatic transdifferentiation".DEVELOPMENTAL CELL 56.22(2021):3115-+. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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