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Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish

文献类型：期刊论文

作者Hamid, Naima1,4,5; Junaid, Muhammad2; Manzoor, Rakia1,3; Duan, Jin-Jing4; Lv, Ming2; Xu, Nan2; Pei, De-Sheng4
刊名AQUATIC TOXICOLOGY
出版日期2022
卷号242页码:11
关键词PPCPs toxicity Xenoestrogens HPG axis Estrogen receptors Molecular docking
ISSN号0166-445X
DOI10.1016/j.aquatox.2021.106040
通讯作者Xu, Nan(xunan@pkusz.edu.cn) ; Pei, De-Sheng(peids@cqmu.edu.cn)
英文摘要Pharmaceuticals and personal care products (PPCPs) as emerging contaminants are ubiquitously present in the aquatic environment. Using in vivo and in silico techniques, this study aims to elucidate tissue distribution and endocrine disruption effects of chronic exposure (120 days) to PPCP mixture at environmentally relevant concentrations (ERCs) in adult zebrafish. Results from UHPLC-MS/MS analyses showed elevated distribution of PPCPs in zebrafish tissues in the order of liver > gonad > brain. Upregulation of steroid hormone receptors, both gonadotropin, and steroidogenic genes perturb the HPG axis pathway in females, while male fish exhibited significantly downregulated expressions of vtg, cyp17, and 17 beta hsd genes with inhibited fecundity. The Spearman correlation indicated a significant positive relationship between PPCPs bioaccumulation and mRNA levels of HPG axis genes. In silico molecular docking (MD) revealed specific amino acid residues of PPCPs binding with zebrafish estrogen receptors. Furthermore, the strongest binding energies of sulfamethoxazole, carbamazepine, and triclosan were discovered in er alpha and er beta estrogen receptors, confirming PPCPs' xenoestrogenic behavior. To summarize, chronic exposure to ERCs resulted in a high accumulation of PPCPs in the liver and gonad tissues of adult zebrafish, as well as associated perturbed genetic responses. As a result, strict environmental regulations for the disposal of PPCPs should be ensured to protect ecological and public health.
资助项目Chongqing Medical University[R4014] ; CAS Team Project of the Belt and Road, Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxmX0035] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; International Partnership Program of CAS[121311kysb20190071] ; CAS-TWAS Scholarship[2017A8018537001] ; National Natural Science Foundation of China[51579003] ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by Chinese Academy of Sciences (CAS)/China-Sri Lanka Joint Center for Education and Research by CAS
WOS研究方向Marine & Freshwater Biology ; Toxicology
语种英语
WOS记录号WOS:000728557800001
出版者ELSEVIER
源URL[http://119.78.100.138/handle/2HOD01W0/14707]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Xu, Nan; Pei, De-Sheng
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Peking Univ, Sch Environm & Energy, Shenzhen Grad Sch, Key Lab Heavy Met Pollut Control & Reutilizat, Shenzhen 518055, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China
4.Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China
5.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
推荐引用方式
GB/T 7714		 Hamid, Naima,Junaid, Muhammad,Manzoor, Rakia,et al. Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish[J]. AQUATIC TOXICOLOGY,2022,242:11.
APA Hamid, Naima.,Junaid, Muhammad.,Manzoor, Rakia.,Duan, Jin-Jing.,Lv, Ming.,...&Pei, De-Sheng.(2022).Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish.AQUATIC TOXICOLOGY,242,11.
MLA Hamid, Naima,et al."Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish".AQUATIC TOXICOLOGY 242(2022):11.

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来源：重庆绿色智能技术研究院

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