TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis
文献类型：期刊论文
| 作者 | Liu, Xin1; Zheng, Xinchuan2; Lu, Yongling1; Chen, Qian1; Zheng, Jiang1; Zhou, Hong3,4 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2021-11-26 |
| 卷号 | 12页码:9 |
| 关键词 | sepsis TFEB TFEB activators autophagy-lysosomal pathway inflammation immunity |
| DOI | 10.3389/fphar.2021.794298 |
| 通讯作者 | Zheng, Jiang(zhouh64@163.com) ; Zhou, Hong(zhengj99219@163.com) |
| 英文摘要 | Sepsis is a life-threatening syndrome induced by aberrant host response towards infection. The autophagy-lysosomal pathway (ALP) plays a fundamental role in maintaining cellular homeostasis and conferring organ protection. However, this pathway is often impaired in sepsis, resulting in dysregulated host response and organ dysfunction. Transcription factor EB (TFEB) is a master modulator of the ALP. TFEB promotes both autophagy and lysosomal biogenesis via transcriptional regulation of target genes bearing the coordinated lysosomal expression and regulation (CLEAR) motif. Recently, increasing evidences have linked TFEB and the TFEB dependent ALP with pathogenetic mechanisms and therapeutic implications in sepsis. Therefore, this review describes the existed knowledge about the mechanisms of TFEB activation in regulating the ALP and the evidences of their protection against sepsis, such as immune modulation and organ protection. In addition, TFEB activators with diversified pharmacological targets are summarized, along with recent advances of their potential therapeutic applications in treating sepsis. |
| 资助项目 | National Natural Science Foundation[81873955] ; National Natural Science Foundation[81772137] ; National Natural Science Foundation[81803394] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000728972800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/14716]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Zheng, Jiang; Zhou, Hong |
| 作者单位 | 1.Army Mil Med Univ, Southwest Hosp, Med Res Ctr, Chongqing, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China 3.Zunyi Med Univ, Minist Educ, Key Lab Basic Pharmacol, Zunyi, Guizhou, Peoples R China 4.Zunyi Med Univ, Minist Educ, Joint Int Res Lab Ethnomed, Zunyi, Guizhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xin,Zheng, Xinchuan,Lu, Yongling,et al. TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis[J]. FRONTIERS IN PHARMACOLOGY,2021,12:9. |
| APA | Liu, Xin,Zheng, Xinchuan,Lu, Yongling,Chen, Qian,Zheng, Jiang,&Zhou, Hong.(2021).TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis.FRONTIERS IN PHARMACOLOGY,12,9. |
| MLA | Liu, Xin,et al."TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis".FRONTIERS IN PHARMACOLOGY 12(2021):9. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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