Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus
文献类型：期刊论文
| 作者 | Peng, Haibo1,2; Xie, Beibei2; Cen, Xianfeng1; Dai, Jiaojiao2; Dai, Yuanwei2; Yang, Xiaohong1,2; He, Yun2 |
| 刊名 | MATERIALS CHEMISTRY FRONTIERS
 |
| 出版日期 | 2021-12-07 |
| 页码 | 8 |
| DOI | 10.1039/d1qm01459e |
| 通讯作者 | Yang, Xiaohong(yangxiaohong@cigit.ac.cn) ; He, Yun(yun.he@cqu.edu.cn) |
| 英文摘要 | MRSA can evade the immune system once they are engulfed by phagocytic host cells. This protects them against the bactericidal action of antibiotics and allows the infection to remain latent or to recur. In this work, a glutathione (GSH)-responsive multifunctional antibiotic delivery system (WP5 superset of G) based on the host-guest interaction between mannose-modified pillar[5]arene (WP5) and a near-infrared (NIR) fluorescence receptor (G) was successfully developed. WP5 superset of G could encapsulate hydrophobic antibiotics such as linezolid (LZD) to form drug-loaded nanoparticles (LZD-WP5 superset of G), improving the anti-intracellular MRSA activity of LZD with excellent biocompatibility. This easily prepared and flexible system could be employed for simultaneous non-invasive cellular imaging and real-time monitoring of antibiotic release, representing a novel strategy toward targeted antibiotic delivery into macrophages for treating intracellular bacterial infections. |
| 资助项目 | Chongqing Postdoctoral Science Special Foundation[E1396401] ; Postdoctoral project of Natural Science Foundation of Chongqing Science and Technology Bureau[cstc2021jcyj-bsh0071] ; National Natural Science Foundation of China[22071012] ; National Natural Science Foundation of China[8210130360] ; National Natural Science Foundation of China[22101036] ; Natural Science Foundation of Chongqing Science and Technology Bureau[cstc2020jcyj-msxmX0936] |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000739580200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/14990]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Yang, Xiaohong; He, Yun |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Haibo,Xie, Beibei,Cen, Xianfeng,et al. Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus[J]. MATERIALS CHEMISTRY FRONTIERS,2021:8. |
| APA | Peng, Haibo.,Xie, Beibei.,Cen, Xianfeng.,Dai, Jiaojiao.,Dai, Yuanwei.,...&He, Yun.(2021).Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus.MATERIALS CHEMISTRY FRONTIERS,8. |
| MLA | Peng, Haibo,et al."Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus".MATERIALS CHEMISTRY FRONTIERS (2021):8. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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