Targeted delivery and enhanced uptake of chemo-photodynamic nanomedicine for melanoma treatment
文献类型：期刊论文
| 作者 | Huang, Xiaobei1; Mu, Ning2,3; Ding, Yuanfu4; Lam, Hou Wang4; Yue, Ludan4; Gao, Cheng4; Chen, Tunan2,3; Yuan, Zhen5; Wang, Ruibing4 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2022-07-15 |
| 卷号 | 147页码:356-365 |
| 关键词 | Photodynamic-chemotherapeutic therapy Pt(IV) prodrug Charge -reversal Targeted drug delivery Controlled drug release |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2022.05.015 |
| 通讯作者 | Chen, Tunan(ctn@tmmu.edu.cn) ; Yuan, Zhen(zhenyuan@um.edu.mo) ; Wang, Ruibing(rwang@um.edu.mo) |
| 英文摘要 | Nanoparticles (NPs) modified with targeting ligands have often shown great potential in targeted drug delivery for tumor therapy. However, the clearance of NPs by the monocyte-phagocyte system (MPS) and the relatively low cellular uptake by tumor cells have significantly limited the antitumor efficacy of a variety of nanomedicines. Tumor microenvironment-mediated multidrug resistance also reduces the an-titumor efficacy of internalized nanomedicines. Herein, we developed an innovative nanomedicine for combined chemo-photodynamic therapy of melanoma through targeted drug delivery and significantly improved the cellular uptake of the nanomedicine through the charge-reversal phenomenon. An am-phiphilic platinum (IV)-polyethylenimine-chlorin e6 (Pt(IV)-PEI-Ce6) polymer was designed, prepared, and self-assembled into NPs (PPC) in an aqueous solution, and these NPs were subsequently coated with hyaluronic acid (HA) to afford PPC@HA. The surface-coated HA provided PPC with a negatively charged surface potential to reduce the clearance by the MPS during systemic circulation and enhanced the tar-geted delivery of PPC to CD44-overexpressing melanoma cells. Upon accumulation in the tumor site, hyaluronidase overexpressed in the tumor induced HA degradation to release the positively charged PPC, resulting in an increased internalization of PPC into tumor cells. Bioactive Pt(II) was released in response to high glutathione level in the tumor cells for effective tumor chemotherapy. Under 650 nm laser irradi-ation, Ce6 produced reactive oxygen species (ROS), thus driving photodynamic therapy. Finally, PPC@HA exhibited combined photodynamic-chemotherapeutic antitumor efficacy against the melanoma cells in mice. |
| 资助项目 | Science and Technology Development Fund, Macau SAR[MYRG2017-00010-ICMS] ; Science and Technology Development Fund, Macau SAR[MYRG2019-00059-ICMS] ; Science and Technology Development Fund, Macau SAR[MYRG2018-00081-FHS] ; SKL-QRCM (UM)[MYRG2019-00082-FHS] ; SKL-QRCM (UM)[MYRG 2020-00067-FHS] ; SKL-QRCM (UM)[SKL-QRCM (UM) -2020-2022] ; SKL-QRCM (UM)[0011/2018/A1] ; SKL-QRCM (UM)[0020/2019/AMJ] ; University of Macau[MYRG2019-00082-FHS] ; University of Macau[MYRG 2020-00067-FHS] ; University of Macau[SKL-QRCM (UM) -2020-2022] ; University of Macau[0011/2018/A1] ; University of Macau[0020/2019/AMJ] ; Talents Training Program of Army Medical University[MYRG2017-00010-ICMS] ; National Natural Science Foundation of China (NSFC)[MYRG2019-00059-ICMS] ; [2019MPRC021/SWH2018QNWQ-05] ; [8102067] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000829655400009 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/15982]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Chen, Tunan; Yuan, Zhen; Wang, Ruibing |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China 2.Army Mil Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing 400038, Peoples R China 3.Army Mil Med Univ, Third Mil Med Univ, Southwest Hosp, Key Lab Neurotrauma, Chongqing 400038, Peoples R China 4.Univ Macau, Macau 999078, Peoples R China 5.Univ Macau, Fac Hlth Sci, Ave Univ, Taipa 999078, Macau, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xiaobei,Mu, Ning,Ding, Yuanfu,et al. Targeted delivery and enhanced uptake of chemo-photodynamic nanomedicine for melanoma treatment[J]. ACTA BIOMATERIALIA,2022,147:356-365. |
| APA | Huang, Xiaobei.,Mu, Ning.,Ding, Yuanfu.,Lam, Hou Wang.,Yue, Ludan.,...&Wang, Ruibing.(2022).Targeted delivery and enhanced uptake of chemo-photodynamic nanomedicine for melanoma treatment.ACTA BIOMATERIALIA,147,356-365. |
| MLA | Huang, Xiaobei,et al."Targeted delivery and enhanced uptake of chemo-photodynamic nanomedicine for melanoma treatment".ACTA BIOMATERIALIA 147(2022):356-365. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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