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Molecular mechanism of Pulmonary diseases caused by exposure to urban PM2.5 in Chengdu-Chongqing Economic Circle, China

文献类型：期刊论文

作者Zhang, Shumin1,2; Zhang, Ronghua1; Guo, Dongmei1; Han, Yan; Song, Guiqin1; Yang, Fumo3; Chen, Yang2
刊名ENVIRONMENT INTERNATIONAL
出版日期2022-07-01
卷号165页码:13
关键词Pulmonary disease TP53 Small cell carcinoma of the lung Chengdu-Chongqing Economic Circle
ISSN号0160-4120
DOI10.1016/j.envint.2022.107292
通讯作者Chen, Yang(chenyang@cigit.ac.cn)
英文摘要Chengdu-Chongqing Economic Circle (CD-CQ Economic Circle) is one of China's four major economic circles and five major urban agglomerations located in Southwest China's Sichuan Basin. The CD-CQ Economic Circle, with its strong economic development and dense population, suffers from severe PM2.5 pollution, which is known to cause chronic and acute respiratory ailments. This study examined the lung disease-related hub genes, functions, and pathways that are affected by PM2.5 in summer and winter in the two central megacities of Chengdu and Chongqing. PM2.5 frequently activates lung disease-associated hub genes, most notably the transcription factor TP53. TP53 interacts with the majority of lung disease-related genes and regulates important and commonly occurring biological functions and pathways, including gland development, aging, reactive oxygen species metabolic process, the response to oxygen levels, and fluid shear stress, among others. Thus, PM2.5 has been shown to target TP53 for regulating lung disease genes/functions/pathways, thereby influencing the occurrence and progression of lung illnesses. Notably, PM2.5 may be associated with small cell carcinoma of the lung due to the high number of lung disease genes, hub genes, critical functions, and pathways enriched in this kind of cancer. These findings shed fresh light on the molecular pathophysiology of PM2.5 pollution on the respiratory system in the CD-CQ Economic Circle and aid in the development of novel techniques for mitigating PM2.5 pollution-associated respiratory illness.
资助项目National High Technology Research and Development Program of China[2018YFC0214002] ; National Natural Science Foundation of China[42107452] ; Nanchong Science and Technology Project[20SXQT0221] ; PhD Research Fund of North Sichuan Medical College[CBY19-QD04]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000806366300008
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.138/handle/2HOD01W0/16178]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Chen, Yang
作者单位1.North Sichuan Med Coll, Sch Basic Med Sci & Forens Med, Nanchong 637000, Sichuan, Peoples R China
2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Res Ctr Atmospher Environm, Chongqing 400714, Peoples R China
3.Sichuan Univ, Coll Architecture & Environm, Chengdu 610065, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Shumin,Zhang, Ronghua,Guo, Dongmei,et al. Molecular mechanism of Pulmonary diseases caused by exposure to urban PM2.5 in Chengdu-Chongqing Economic Circle, China[J]. ENVIRONMENT INTERNATIONAL,2022,165:13.
APA Zhang, Shumin.,Zhang, Ronghua.,Guo, Dongmei.,Han, Yan.,Song, Guiqin.,...&Chen, Yang.(2022).Molecular mechanism of Pulmonary diseases caused by exposure to urban PM2.5 in Chengdu-Chongqing Economic Circle, China.ENVIRONMENT INTERNATIONAL,165,13.
MLA Zhang, Shumin,et al."Molecular mechanism of Pulmonary diseases caused by exposure to urban PM2.5 in Chengdu-Chongqing Economic Circle, China".ENVIRONMENT INTERNATIONAL 165(2022):13.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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