中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 重庆绿色智能技术研究院
  3. 中国科学院重庆绿色智能技术研究院
Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling

文献类型：期刊论文

作者Xu, Yuhang1,2; Luo, Lingfei1,3; Chen, Jingying1
刊名ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期2022-06-15
卷号238页码:9
关键词Sulfamethoxazole Brain capillaries toxicity Brain oedema VEGF Chemokine
ISSN号0147-6513
DOI10.1016/j.ecoenv.2022.113620
通讯作者Chen, Jingying(jingyingchen@cigit.ac.cn)
英文摘要Sulfamethoxazole (SMX) is a widespread broad-spectrum bacteriostatic antibiotic. Its residual is frequently detected in the water and may therefore bioaccumulate in the brain of aquatic organisms via blood circulation. Brain capillaries toxicity is very important for brain development. However, little information is available in the literature to show the toxicity of SMX to brain development. To study the SMX's brain toxic effects and the related mechanisms, we exposed zebrafish embryos to SMX at different concentrations (0 ppm, 1 ppm, 25 ppm, 100 ppm and 250 ppm) and found that high concentration (250 ppm) of SMX would not only caused an abnormal in malformation rate, hatching rate, body length and survival rate of zebrafish embryos, but also lead to brain oedema. In addition, SMX also induced cerebral ischaemia, aggravates oxidative stress, and changes genes related to oxidative stress (sod1, cat, gpx4, and nrf2). Furthermore, ischaemia caused by SMX could promote ectopic angiogenesis in brain via activating the angiogenesis-related genes (vegfab, cxcr4a, cxcl12b) from 24 h to 53 h. Inhibition of VEGF signalling by SU5416, or inhibition of chemokine downstream PI3K signalling by LY294002, could rescue the brain capillaries toxicity and brain oedema induced by SMX. Our results provide new evidence for the brain toxicity of SMX and its residual danger in the environment and aquatic organisms.
资助项目National Natural Science Foundation of China[32192400] ; National Natural Science Foundation of China[32000576] ; National Key R&D Program of China[2021YFA0805000] ; Natural Science Foundation of Chongq-ing[cstc2020jcyj-msxmX0882] ; 111 Program[B14037]
WOS研究方向Environmental Sciences & Ecology ; Toxicology
语种英语
WOS记录号WOS:000803734000002
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.138/handle/2HOD01W0/16239]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Chen, Jingying
作者单位1.Univ Chinese Acad Sci Chongqing, Chongqing Inst Green & Intelligent Technol, Chinese Acad Sci, Beibei, Chongqing 400714, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Southwest Univ, Inst Dev Biol & Regenerat Med, Beibei, Chongqing 400715, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yuhang,Luo, Lingfei,Chen, Jingying. Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,238:9.
APA Xu, Yuhang,Luo, Lingfei,&Chen, Jingying.(2022).Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,238,9.
MLA Xu, Yuhang,et al."Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 238(2022):9.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。