Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)
文献类型：期刊论文
| 作者 | Zhao Heling1,2; Yang Hongsheng1 ; Zhao Huan1,2; Liu Shilin1; Wang Tianming1,2
|
| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 30期号:1页码:80-91 |
| 关键词 | microphthalmia-associated transcription factor (MITF) melanocyte melanosome melanin Apostichopus japonicus |
| ISSN号 | 0254-4059 |
| 通讯作者 | Yang, HS (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 英文摘要 | Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism, we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition, we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes, which also contained less melanin. In albino juvenile offspring, MITF expression levels were significantly lower 32 d after fertilization and there were fewer, and less developed, epidermal melanocytes. Thus, we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin, likely because of lower expression of MITF. |
| 学科主题 | Limnology ; Oceanography |
| 收录类别 | SCI |
| 原文出处 | 10.1007/s00343-012-1043-9 |
| 语种 | 英语 |
| WOS记录号 | WOS:000299040100008 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12418]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Heling,Yang Hongsheng,Zhao Huan,et al. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(1):80-91. |
| APA | Zhao Heling,Yang Hongsheng,Zhao Huan,Liu Shilin,&Wang Tianming.(2012).Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka).CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(1),80-91. |
| MLA | Zhao Heling,et al."Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.1(2012):80-91. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。