Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles
文献类型：期刊论文
| 作者 | Cao, Liang1; Huang, Wei1,2; Shan, Xiujuan1,3; Ye, Zhenjiang4; Dou, Shuozeng1 |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:1页码:16-25 |
| ISSN号 | 1382-6689 |
| 关键词 | Cd Antioxidants LPO Accumulation Japanese flounder |
| 通讯作者 | Dou, SZ (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 英文摘要 | This study investigated the accumulation of cadmium (0-8 mg Cd L-1) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28 d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at >= 4 mg L-1 Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue. (C) 2011 Published by Elsevier B.V. |
| 学科主题 | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| 收录类别 | SCI |
| 原文出处 | 10.1016/j.etap.2011.10.003 |
| 语种 | 英语 |
| WOS记录号 | WOS:000301876600003 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12450]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.State Ocean Adm, Lab Marine Ecosyst & Biogeochem, Inst Oceanog 2, Hangzhou 310012, Zhejiang, Peoples R China 3.Chinese Acad Fishery Sci, Yellow Sea Fishery Res Inst, Qingdao 266071, Peoples R China 4.Ocean Univ China, Fishery Coll, Qingdao 266003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Liang,Huang, Wei,Shan, Xiujuan,et al. Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,33(1):16-25. |
| APA | Cao, Liang,Huang, Wei,Shan, Xiujuan,Ye, Zhenjiang,&Dou, Shuozeng.(2012).Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,33(1),16-25. |
| MLA | Cao, Liang,et al."Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 33.1(2012):16-25. |
入库方式： OAI收割
来源：海洋研究所
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