Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure
文献类型：期刊论文
| 作者 | Fang, Yan1,2; Yang, Hongsheng1 ; Liu, Baozhong1
|
| 刊名 | ECOTOXICOLOGY
 |
| 出版日期 | 2012-08-01 |
| 卷号 | 21期号:6页码:1593-1602 |
| ISSN号 | 0963-9292 |
| 关键词 | Metallothionein Superoxide dismutase Mercury mRNA expression Mactra veneriformis |
| 通讯作者 | Yang, HS (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China. |
| 英文摘要 | To identify the relationship between mercury (Hg) and stress responses in the clam Mactra veneriformis, metallothionein (MT) and superoxide dismutase (SOD) mRNA expression in the digestive gland, gill, and mantle as well as MT protein content and SOD activity in the digestive gland were examined under sublethal Hg exposure at doses of 10, 20, and 40 mu g/L for 21 days. The ranking of the tissues in decreasing order of their basal MvMT and MvSOD mRNA expression is as follows: digestive gland > mantle > gill > adductor muscle > foot and digestive gland > mantle > gill > foot > adductor muscle, respectively. Hg exposure significantly elevated MvMT and MvSOD mRNA transcripts in the digestive gland, gill, and mantle in a tissue-specific way. In the digestive gland, a dose-dependent increase of MvMT and MvSOD mRNA expression, stimulation of MT protein, and alteration of SOD activity were observed under Hg stress. MT protein responded later than MT mRNA to Hg exposure and no clear relationship was found between them, indicating the occurrence of posttranscriptional events. All of the results suggest that MT and SOD cooperate in resisting Hg toxicity and maintaining cellular metabolic homeostasis in M. veneriformis. MT and SOD mRNA expressions have great potential as biomarkers of Hg pollution in the aquatic environment for the studied species. |
| 学科主题 | Ecology ; Environmental Sciences ; Toxicology |
| 收录类别 | SCI |
| 原文出处 | 10.1007/s10646-012-0938-8 |
| 语种 | 英语 |
| WOS记录号 | WOS:000306592100003 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12452]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Yan,Yang, Hongsheng,Liu, Baozhong. Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure[J]. ECOTOXICOLOGY,2012,21(6):1593-1602. |
| APA | Fang, Yan,Yang, Hongsheng,&Liu, Baozhong.(2012).Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure.ECOTOXICOLOGY,21(6),1593-1602. |
| MLA | Fang, Yan,et al."Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure".ECOTOXICOLOGY 21.6(2012):1593-1602. |
入库方式： OAI收割
来源：海洋研究所
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