Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy
文献类型：期刊论文
| 作者 | Xu, Fang-Zhou7; Zhu, Ling7; Han, Hai-Hao5,7; Zou, Jian-Wei6; Zang, Yi5 ; Li, Jia2,4,5; James, Tony D.1,3; He, Xiao-Peng7; Wang, Cheng-Yun7
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| 刊名 | CHEMICAL SCIENCE
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| 出版日期 | 2022-08-03 |
| 页码 | 8 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d2sc00889k |
| 通讯作者 | Zou, Jian-Wei(jwzou@nit.net.cn) ; Li, Jia(jli@simm.ac.cn) ; James, Tony D.(t.d.james@bath.ac.uk) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Wang, Cheng-Yun(cywang@ecust.edu.cn) |
| 英文摘要 | Luminogens characteristic of aggregation-induced emission (AIEgens) have been extensively exploited for the development of imaging-guided photodynamic therapeutic (PDT) agents. However, intramolecular rotation of donor-acceptor (D-A) type AIEgens favors non-radiative decay of photonic energy which results in unsatisfactory fluorescence quantum and singlet oxygen yields. To address this issue, we developed several molecularly engineered AIEgens with partially "locked" molecular structures enhancing both fluorescence emission and the production of triplet excitons. A triphenylphosphine group was introduced to form a D-A conjugate, improving water solubility and the capacity for mitochondrial localization of the resulting probes. Experimental and theoretical analyses suggest that the much higher quantum and singlet oxygen yield of a structurally "significantly-locked" probe (LOCK-2) than its "partially locked" (LOCK-1) and "unlocked" equivalent (LOCK-0) is a result of suppressed AIE and twisted intramolecular charge transfer. LOCK-2 was also used for the mitochondrial-targeting, fluorescence image-guided PDT of liver cancer cells. |
| WOS关键词 | AGGREGATION-INDUCED EMISSION ; PHOTOSENSITIZERS ; DESIGN ; PROGRESS ; DISEASE |
| 资助项目 | National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; Shanghai Science and Technology Committee[19410712600] ; Natural Science Foundation of Shanghai[22ZR1417300] ; China Postdoctoral Science Foundation[2020M681196] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000835919800001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301881]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zou, Jian-Wei; Li, Jia; James, Tony D.; He, Xiao-Peng; Wang, Cheng-Yun |
| 作者单位 | 1.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 6.NingboTech Univ, Ningbo 315100, Zhejiang, Peoples R China 7.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr,Key L, Frontiers Ctr Mat & Dynam Chem,Sch Chem & Mol Eng, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Fang-Zhou,Zhu, Ling,Han, Hai-Hao,et al. Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy[J]. CHEMICAL SCIENCE,2022:8. |
| APA | Xu, Fang-Zhou.,Zhu, Ling.,Han, Hai-Hao.,Zou, Jian-Wei.,Zang, Yi.,...&Wang, Cheng-Yun.(2022).Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy.CHEMICAL SCIENCE,8. |
| MLA | Xu, Fang-Zhou,et al."Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy".CHEMICAL SCIENCE (2022):8. |
入库方式： OAI收割
来源：上海药物研究所
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