A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging
文献类型：期刊论文
| 作者 | Lou, Hongyue4,5; Ji, Aiyan4; Qu, Chunrong4; Liu, Hongguang5; Jiang, Lei3; Chen, Hao2,4; Cheng, Zhen1,2,4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2022-07-28 |
| 页码 | 12 |
| ISSN号 | 1944-8244 |
| 关键词 | NIR-IIb fluorophore osteosarcoma imaging guided surgery photothermal therapy |
| DOI | 10.1021/acsami.2c11706 |
| 通讯作者 | Jiang, Lei(leijiang1031@163.com) ; Chen, Hao(haoc@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Near-infrared window IIb (NIR-IIb, 1500-1700 nm) fluorescence imaging demonstrates attractive properties including low scattering, low absorption, and deep tissue penetration, and photothermal therapy (PTT) is also a promising modality for cancer treatment. However, until now, there is no report on theranostic systems based on small organic molecules combining fluorescence imaging in the NIR-IIb and PTT, highlighting the challenge and strong need for development of such agents. Herein, we report a novel small molecule NIR-IIb dye IT-TQF with a D-A-D structure, which exhibited high fluorescence intensity in the NIR-IIb window. To further translate IT-TQF into an effective theranostic agent, IT-TQF was encapsulated into DSPE-PEG2000 to construct IT-TQF NPs. The physical and photochemical properties of the nanoprobe were investigated in vitro, and the in vivo NIR-IIb imaging and PTT performance were evaluated in normal, subcutaneous, orthotopic, and metastatic tumor mice models. IT-TQF NP-based NIR-IIb imaging demonstrated high spatial resolution and high tissue penetration depth, and small normal blood vessels (55.3 mu m) were successfully imaged in the NIR-IIb window. Subcutaneous, orthotopic, and metastatic tumors were all clearly delineated. A high tumor signal-to-background ratio (SBR) of 9.42 was achieved for orthotopic osteosarcoma models, and the erosions of bone tissue caused by tumor cells were precisely visualized. Moreover, NIR-II image-guided surgery was successfully performed to completely remove the orthotopic tumor. Importantly, IT-TQF NPs displayed high PTT efficacy (photothermal conversion efficiency: 47%) for effective treatment of tumor mice. In conclusion, IT-TQF NPs are a novel and promising phototheranostic agent in the NIR-IIb window, and the nanoprobe has high potential for a broad range of biomedical applications. |
| WOS关键词 | SURFACE-CHEMISTRY ; IN-VIVO ; SIZE ; FLUOROPHORES |
| 资助项目 | National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900] ; Lingang Laboratory[LG-QS-202206-01] ; National Natural Science Foundation of China[82071976] ; National Natural Science Foundation of China[81901799] ; National Natural Science Foundation of China[81971645] ; Shanghai Pujiang Program[19PJ1411100] ; Guangdong Provincial People's Hospital[KY0120211130] ; Guangdong Provincial People?s Hospital ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000835263600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301890]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Lei; Chen, Hao; Cheng, Zhen |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, PET Ctr, Dept Nucl Med, Guangzhou 510080, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Northeastern Univ, Inst Mol Med, Joint Lab Mol Med, Shenyang 110000, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lou, Hongyue,Ji, Aiyan,Qu, Chunrong,et al. A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2022:12. |
| APA | Lou, Hongyue.,Ji, Aiyan.,Qu, Chunrong.,Liu, Hongguang.,Jiang, Lei.,...&Cheng, Zhen.(2022).A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging.ACS APPLIED MATERIALS & INTERFACES,12. |
| MLA | Lou, Hongyue,et al."A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging".ACS APPLIED MATERIALS & INTERFACES (2022):12. |
入库方式： OAI收割
来源：上海药物研究所
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