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Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit alpha-Glucosidase and ATP-Citrate Lyase

文献类型：期刊论文

作者Chen, Shanji4,5; Tian, Danmei4,5; Wei, Jihua3; Li, Cong2; Ma, Yihan3; Gou, Xiaoshuang4,5; Shen, Yiran2; Chen, Mei4,5; Zhang, Sihao4,5; Li, Jia1,2
刊名FRONTIERS IN MARINE SCIENCE
出版日期2022-07-22
卷号9页码:11
关键词Penicillium citrinum Y34 citrinin dimer alpha-Glucosidase inhibitory activity ACL inhibitory activity molecular docking
DOI10.3389/fmars.2022.961356
通讯作者Wu, Bin(wubin@zju.edu.cn) ; Tang, Jinshan(gztangjinshan@126.com)
英文摘要Two new citrinin dimers bearing a 6,6-spiroketal moiety (1 and 2) and four known analogues (3-6), together with 18 known citrinin monomers (7-24), were isolated from the culture of hydrothermal vent-associated fungus Penicillium citrinum Y34. Their structures were identified by extensive spectroscopic analyses, C-13 NMR calculation in combination with DP4+, linear correlation coefficient (R-2), and mean absolute error (MAE) values analyses, and electronic circular dichroism (ECD) calculation. The alpha-glucosidase and ATP-citrate lyase (ACL) inhibitory activities of isolated compounds were evaluated. Compounds 1, 3, and 12 displayed moderate alpha-glucosidase inhibitory activities with IC50 values of 239.8, 176.2, and 424.4 mu M, respectively. Enzyme kinetics investigations of 1 and 3 suggested their non-competitive inhibition of alpha-glucosidase with K-i values of 204.3 and 212.7 mu M, respectively. Meanwhile, compound 4 showed significant ACL inhibitory potential with an IC50 value of 17.4 mu M. Furthermore, the interactions of 1, 3, and 12 with alpha-glucosidase and 4 with ACL were investigated by molecular docking assay. This study demonstrates that citrinins, especially for their dimers, could be potential lead compounds for the development of new agents for the treatment of metabolic diseases.
WOS关键词ENDOPHYTIC FUNGUS ; MYCOTOXIN CITRININ ; POLYKETIDES ; METABOLITES ; ANTIOXIDANT
资助项目National Key Research and Development Program of China[2018YFC0311002] ; Guangzhou Basic and Applied Basic Foundation[202201010305] ; National Nature Science Foundation of China[41876148]
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology
语种英语
WOS记录号WOS:000837274300001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/301905]  
专题新药研究国家重点实验室
通讯作者Wu, Bin; Tang, Jinshan
作者单位1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai, Peoples R China
3.Zhejiang Univ, Ocean Coll, Hangzhou, Peoples R China
4.Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China
5.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shanji,Tian, Danmei,Wei, Jihua,et al. Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit alpha-Glucosidase and ATP-Citrate Lyase[J]. FRONTIERS IN MARINE SCIENCE,2022,9:11.
APA Chen, Shanji.,Tian, Danmei.,Wei, Jihua.,Li, Cong.,Ma, Yihan.,...&Tang, Jinshan.(2022).Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit alpha-Glucosidase and ATP-Citrate Lyase.FRONTIERS IN MARINE SCIENCE,9,11.
MLA Chen, Shanji,et al."Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit alpha-Glucosidase and ATP-Citrate Lyase".FRONTIERS IN MARINE SCIENCE 9(2022):11.

入库方式： OAI收割

来源：上海药物研究所

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