Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines
文献类型：期刊论文
| 作者 | Zheng, Fuqiang2,3; Zhou, Jianhui3; Fang, Feifei3; Li, Jiyuan3; Wang, Jing3; Zheng, Miao3; Liu, Hong1,2,3 ; Xu, Yungen2; Zhou, Yu1,3
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2022-08-03 |
| 页码 | 5 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.2c02070 |
| 通讯作者 | Xu, Yungen(xyg@cpu.edu.cn) ; Zhou, Yu(zhouyu@simm.ac.cn) |
| 英文摘要 | A Rh(III)-catalyzed C-H activation of alpha-keto oximes and a cyclization cascade with diazo compounds were developed to construct the highly fused indano[1,2-b]azirine frameworks in good yields with a broad range of substrates under mild reaction conditions. More intriguingly, a [4+1+1] sequential annulation cascade is demonstrated for the first time in this reaction and opened a new reaction mode for alpha-keto oximes. These fused indano[1,2-b]azirine derivatives could also be further transformed into intriguing privileged drug scaffolds. |
| WOS关键词 | ASYMMETRIC CATALYTIC AZIRIDINATION ; N-BOC IMINES ; DIAZO-COMPOUNDS ; FACILE SYNTHESIS ; FUNCTIONALIZATION ; INHIBITORS ; LACTAMS ; DESIGN ; ACCESS ; GAMMA |
| 资助项目 | National Natural Science Foundation of China[82173656] ; National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[81903434] ; National Natural Science Foundation of China[82103969] ; Strategic Priority Research Program of Chinese Academy of Sciences[SIMM010109] ; Strategic Priority Research Program of Chinese Academy of Sciences[SIMM010111] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000835947800001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301914]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Yungen; Zhou, Yu |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Fuqiang,Zhou, Jianhui,Fang, Feifei,et al. Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines[J]. ORGANIC LETTERS,2022:5. |
| APA | Zheng, Fuqiang.,Zhou, Jianhui.,Fang, Feifei.,Li, Jiyuan.,Wang, Jing.,...&Zhou, Yu.(2022).Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines.ORGANIC LETTERS,5. |
| MLA | Zheng, Fuqiang,et al."Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines".ORGANIC LETTERS (2022):5. |
入库方式： OAI收割
来源：上海药物研究所
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