Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy
文献类型：期刊论文
| 作者 | Wu, Fengxia2,3; Chen, Haoran2; Liu, Ruiqi3; Suo, Yongkuan3; Li, Qiqing2; Zhang, Youlin2; Liu, Hongguang3; Cheng, Zhen1; Chang, Yulei2 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2022-07-27 |
| 页码 | 10 |
| ISSN号 | 2192-2640 |
| 关键词 | immune response nanozymes NIR-II photothermal therapy oxidative stress reactive oxygen species |
| DOI | 10.1002/adhm.202200809 |
| 通讯作者 | Cheng, Zhen(zcheng@simm.ac.cn) ; Chang, Yulei(yuleichang@ciomp.ac.cn) |
| 英文摘要 | Nanozymes with multienzyme-mimicking activities have shown great potential in cancer therapy due to their ability to modulate the complex tumor microenvironment (TME). Herein, a second near-infrared (NIR-II) photothermal-nanocatalyst by decorating Bi2Te3 nanosheets with ultrasmall Au/Pd bimetallic nanoparticles (Bi2Te3-Au/Pd) to reverse the immunosuppressive TME is developed. The peroxidase (POD)-like and catalase (CAT)-like activities, and glutathione (GSH) consumption capacity of Au/Pd modulates the TME by disrupting the intracellular redox homeostasis and relieving hypoxia in the TME. Notably, the amplified oxidative stress induces the accumulation of lipid hydroperoxides (LPO) for enhanced ferroptosis. Moreover, upon NIR-II photoirradiation at 1064 nm, the localized heat generated by Bi2Te3 not only directly ablates the cancer cells but also enhances the Au/Pd-mediated catalysis-mediated cancer therapy. Furthermore, both in vitro and in vivo studies confirm that the Bi2Te3-Au/Pd nanocatalysts (BAP NCs) can effectively suppress tumor growth by inducing immunogenic cell death (ICD), and suppressing metastasis and recurrence by the synergistic treatment. Overall, this study provides a promising theranostic strategy for effective tumor inhibition. |
| WOS关键词 | AU/PD NANOPARTICLES ; CELL-DEATH ; GOLD |
| 资助项目 | National Natural Science Foundation of China[62075217] ; National Natural Science Foundation of China[11874354] ; National Natural Science Foundation of China[11874355] ; National Natural Science Foundation of China[61575194] ; Project of Science and Technology Agency, Jilin Province[20210101148JC] ; Project of Science and Technology Agency, Jilin Province[202512JC010475440] ; State Key Laboratory of Luminescence and Applications[SKLA-2019-02] ; State Key Laboratory of Luminescence and Applications[SKLA-2020-09] |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000830337800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302016]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen; Chang, Yulei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, Changchun 130033, Jilin, Peoples R China 3.Northeastern Univ, Coll Life & Hlth Sci, Inst Mol Med, Shenyang 110000, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Fengxia,Chen, Haoran,Liu, Ruiqi,et al. Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2022:10. |
| APA | Wu, Fengxia.,Chen, Haoran.,Liu, Ruiqi.,Suo, Yongkuan.,Li, Qiqing.,...&Chang, Yulei.(2022).Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,10. |
| MLA | Wu, Fengxia,et al."Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy".ADVANCED HEALTHCARE MATERIALS (2022):10. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。