Comprehensive Transcriptome Profiling of NAFLD- and NASH-Induced Skeletal Muscle Dysfunction
文献类型：期刊论文
| 作者 | Guo, Mingwei3,4; Xiang, Liping2; Yao, Jing3,4; Zhang, Jun3,4; Zhu, Shuangshuang3,4; Wang, Dongmei3,4; Liu, Caizhi3,4; Li, Guoqiang3,4; Wang, Jiawen1,3,4; Gao, Yuqing1 |
| 刊名 | FRONTIERS IN ENDOCRINOLOGY
 |
| 出版日期 | 2022-02-21 |
| 卷号 | 13页码:14 |
| 关键词 | NAFLD NASH quadriceps muscle lipid deposition insulin resistance myokines |
| ISSN号 | 1664-2392 |
| DOI | 10.3389/fendo.2022.851520 |
| 通讯作者 | Ma, Xinran(xrma@bio.ecnu.edu.cn) ; Xu, Lingyan(lyxu@bio.ecnu.edu.cn) ; Zhou, Jian(zhoujian@sjtu.edu.cn) |
| 英文摘要 | Nonalcoholic fatty liver disease (NAFLD), characterized by extensive triglyceride accumulation in hepatocytes, may progress to nonalcoholic steatohepatitis (NASH) with liver fibrosis and inflammation and increase the risk of cirrhosis, cancer, and death. It has been reported that physical exercise is effective in ameliorating NAFLD and NASH, while skeletal muscle dysfunctions, including lipid deposition and weakness, are accompanied with NAFLD and NASH. However, the molecular characteristics and alterations in skeletal muscle in the progress of NAFLD and NASH remain unclear. In the present study, we provide a comprehensive analysis on the similarity and heterogeneity of quadriceps muscle in NAFLD and NASH mice models by RNA sequencing. Importantly, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway functional enrichment analysis revealed that NAFLD and NASH led to impaired glucose and lipid metabolism and deteriorated functionality in skeletal muscle. Besides this, we identified that myokines possibly mediate the crosstalk between muscles and other metabolic organs in pathological conditions. Overall, our analysis revealed a comprehensive understanding of the molecular signature of skeletal muscles in NAFLD and NASH, thus providing a basis for physical exercise as an intervention against liver diseases. |
| WOS关键词 | FATTY LIVER-DISEASE ; INSULIN-RESISTANCE ; NONALCOHOLIC STEATOHEPATITIS ; PHYSICAL-ACTIVITY ; GLUCOSE-UPTAKE ; EXERCISE ; SARCOPENIA ; METABOLISM ; OBESITY ; RISK |
| 资助项目 | National Key Research and Development Program of China[2019YFA0904500] ; Science and Technology Commission of Shanghai Municipality[21140904300] ; National Natural Science Foundation of China[32022034] ; National Natural Science Foundation of China[31770840] ; National Natural Science Foundation of China[32071148] ; National Natural Science Foundation of China[31800989] ; Fundamental Research Funds for the Central Universities ; ECNU public platform for Innovation[011] ; instruments sharing platform of School of Life Sciences |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000830106000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302028]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ma, Xinran; Xu, Lingyan; Zhou, Jian |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Clin Ctr Diabet, Shanghai Diabet Inst, Dept Endocrinol & Metab,Affiliated Peoples Hosp 6, Shanghai, Peoples R China 3.East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China 4.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Mingwei,Xiang, Liping,Yao, Jing,et al. Comprehensive Transcriptome Profiling of NAFLD- and NASH-Induced Skeletal Muscle Dysfunction[J]. FRONTIERS IN ENDOCRINOLOGY,2022,13:14. |
| APA | Guo, Mingwei.,Xiang, Liping.,Yao, Jing.,Zhang, Jun.,Zhu, Shuangshuang.,...&Zhou, Jian.(2022).Comprehensive Transcriptome Profiling of NAFLD- and NASH-Induced Skeletal Muscle Dysfunction.FRONTIERS IN ENDOCRINOLOGY,13,14. |
| MLA | Guo, Mingwei,et al."Comprehensive Transcriptome Profiling of NAFLD- and NASH-Induced Skeletal Muscle Dysfunction".FRONTIERS IN ENDOCRINOLOGY 13(2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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