Urine D-ribose levels correlate with cognitive function in community-dwelling older adults
文献类型：期刊论文
| 作者 | Zhu,Xinyi2,3 ; Wei,Yan1; He,Yingge1; He,Rongqiao1; Li,Juan2,3
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| 刊名 | BMC Geriatrics
 |
| 出版日期 | 2022-08-22 |
| 卷号 | 22期号:1 |
| 关键词 | D-ribose MMSE Verbal fluency Cognitive impairment Older adults |
| DOI | 10.1186/s12877-022-03288-w |
| 通讯作者 | He,Rongqiao(rongqiaohe@163.com) ; Li,Juan(lijuan@psych.ac.cn) |
| 英文摘要 | AbstractBackgroundD-ribose is involved in the pathogenesis of Alzheimer’s Disease. The study aimed to determine the association between D-ribose and cognitive function in a sample of community-dwelling older adults.MethodsA cross-sectional study was conducted in Chaoyang District, Beijing in 2019–2020. Eligible participants were community-based older adults aged 60?years and above. D-ribose was analyzed from the morning urine. Cognitive function, subjective cognitive decline, and depressive symptoms were measured by a battery of neuropsychological tests. Linear regressions were performed to determine the relationship between the urine D-ribose levels and cognitive performance.ResultsA sample of 1725 participants (67.1% female) aged 60 to 85?years (69.40?±?5.87?years, mean?±?SD) was enrolled in the analysis. The urine D-ribose concentrations ranged from 1.53 to 208.89?μmol/L (median 38.10?μmol/L; interquartile range 22.52—64.96?μmol/L). Higher levels of D-ribose were associated with worse performance on Mini-Mental State Examination and verbal fluency when age, gender, education, depressive symptoms, and cardiovascular risk factors were included as covariates.ConclusionsThe urine D-ribose was negatively correlated with cognitive function in community-dwelling older adults. The findings suggest that the dysmetabolism of D-ribose may play a role at the early stage of cognitive impairment. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12877-022-03288-W |
| 出版者 | BioMed Central |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43102]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | He,Rongqiao; Li,Juan |
| 作者单位 | 1.University of Chinese Academy of Sciences; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics 2.University of Chinese Academy of Sciences; Department of Psychology 3.CAS Key Laboratory of Mental Health, Chinese Academy of Sciences; Center On Aging Psychology, Institute of Psychology |
| 推荐引用方式 GB/T 7714 | Zhu,Xinyi,Wei,Yan,He,Yingge,et al. Urine D-ribose levels correlate with cognitive function in community-dwelling older adults[J]. BMC Geriatrics,2022,22(1). |
| APA | Zhu,Xinyi,Wei,Yan,He,Yingge,He,Rongqiao,&Li,Juan.(2022).Urine D-ribose levels correlate with cognitive function in community-dwelling older adults.BMC Geriatrics,22(1). |
| MLA | Zhu,Xinyi,et al."Urine D-ribose levels correlate with cognitive function in community-dwelling older adults".BMC Geriatrics 22.1(2022). |
入库方式： OAI收割
来源：心理研究所
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