An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors
文献类型：期刊论文
| 作者 | Jin, Jinpu; He, Kun1; Tang, Xing; Li, Zhe3; Lv, Le1; Zhao, Yi; Luo, Jingchu; Gao, Ge |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2015 |
| 卷号 | 32期号:7页码:1767-1773 |
| 关键词 | transcription factor transcriptional regulation network structure novel family wiring preference |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msv058 |
| 文献子类 | Article |
| 英文摘要 | Transcription factors (TFs) play key roles in both development and stress responses. By integrating into and rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence transcriptional regulatory map covering 388 TFs from 47 families in Arabidopsis. Systematic analysis of this map revealed the architectural heterogeneity of developmental and stress response subnetworks and identified three types of novel network motifs that are absent from unicellular organisms and essential for multicellular development. Moreover, TFs of novel families that emerged during plant landing present higher binding specificities and are preferentially wired into developmental processes and these novel network motifs. Further unveiled connection between the binding specificity and wiring preference of TFs explains the wiring preferences of novel-family TFs. These results reveal distinct functional and evolutionary features of novel TFs, suggesting a plausible mechanism for their contribution to the evolution of multicellular organisms. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| 出版地 | OXFORD |
| 电子版国际标准刊号 | 1537-1719 |
| WOS关键词 | FLORAL HOMEOTIC GENES ; NETWORK MOTIFS ; ESCHERICHIA-COLI ; GENOMIC ANALYSIS ; FACTOR-BINDING ; DYNAMICS ; ARCHITECTURE ; PLANT ; BACTERIA ; CIRCUITS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000360585900009 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Natural Science Foundation of China [31470330] ; China 863 Programs [2006AA02Z334] ; State Key Laboratory of Protein and Plant Gene Research ; National Program for Support of Top-notch Young Professionals ; China Postdoctoral Science Foundation [2014M560017] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/25666]  |
| 专题 | 植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文 |
| 作者单位 | 1.Peking Univ, Ctr Bioinformat, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China 3.Monsanto Biotechnol R&D Ctr, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Jinpu,He, Kun,Tang, Xing,et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors[J]. MOLECULAR BIOLOGY AND EVOLUTION,2015,32(7):1767-1773. |
| APA | Jin, Jinpu.,He, Kun.,Tang, Xing.,Li, Zhe.,Lv, Le.,...&Gao, Ge.(2015).An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.MOLECULAR BIOLOGY AND EVOLUTION,32(7),1767-1773. |
| MLA | Jin, Jinpu,et al."An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors".MOLECULAR BIOLOGY AND EVOLUTION 32.7(2015):1767-1773. |
入库方式： OAI收割
来源：植物研究所
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