Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide
文献类型：期刊论文
| 作者 | Zhu, C.; Zeng, Q.; McMichael, A.; Ebi, K. L.; Ni, K.; Khan, A. S.; Zhu, J.; Liu, G.; Zhang, X.; Cheng, Lei4 |
| 刊名 | CLIMATIC CHANGE
 |
| 出版日期 | 2015 |
| 卷号 | 132期号:2页码:295-306 |
| ISSN号 | 0165-0009 |
| DOI | 10.1007/s10584-015-1421-3 |
| 文献子类 | Article |
| 英文摘要 | Although the role of rising atmospheric carbon dioxide concentration [CO2] on plant growth and fecundity is widely acknowledged as important within the scientific community; less research is available regarding the impact of [CO2] on secondary plant compounds, even though such compounds can play a significant role in human health. At present, Artemisia annua, an annual plant species native to China, is widely recognized as the primary source of artemesinin used in artemesinin combination therapies or ACTs. ACTs, in turn, are used globally for the treatment of simple Plasmodium falciparum malaria, the predominant form of malaria in Africa. In this study, artemesinin concentration was quantified for multiple A. annua populations in China using a free-air CO2 enrichment (FACE) system as a function of [CO2]-induced changes both in situ and as a function of the foliar ratio of carbon to nitrogen (C:N). The high correlation between artemesinin concentration and C:N allowed an historical examination of A. annua leaves collected at 236 locations throughout China from 1905 through 2009. Both the historical and experimental data indicate that increases in artemesinin foliar concentration are likely to continue in parallel with the ongoing increase in atmospheric [CO2]. The basis for the [CO2]-induced increase in artemesinin is unclear, but could be related to the carbon: nutrient hypothesis of Bryant et al. (1983). Overall, these data provide the first evidence that historic and projected increases in atmospheric [CO2] may be associated with global changes in artemesinin chemistry, potentially allowing a greater quantity of drug available for the same area of cultivation. |
| 学科主题 | Environmental Sciences ; Meteorology & Atmospheric Sciences |
| 出版地 | DORDRECHT |
| 电子版国际标准刊号 | 1573-1480 |
| WOS关键词 | PLANT-HERBIVORE INTERACTIONS ; ELEVATED CO2 ; ARTEMISIA-ANNUA ; CLIMATE-CHANGE ; NITROGEN ; MALARIA ; GROWTH ; OPTIMIZATION ; TEMPERATURE ; CHALLENGES |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000360541800010 |
| 出版者 | SPRINGER |
| 资助机构 | National Basic Research Program (973 Program) [2014CB954500] ; National Natural Science Foundation of China [31370457, 41301209, 31261140364, 31201126] ; Natural Science Foundation of Jiangsu province in China [BK20131051, BK20140063] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/25752]  |
| 专题 | 植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文 |
| 作者单位 | 1.Khan, A. S.] Univ Nebraska, Med Ctr, Coll Publ Hlth, Omaha, NE 68198 USA 2.Ziska, L. H.] USDA ARS, Crop Syst & Global Change Lab, Beltsville, MD 20705 USA 3.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China 4.Zhang, X.] Chinese Acad Sci, Inst Bot, Herbarium, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 5.Ebi, K. L.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA 6.McMichael, A.] Australian Natl Univ, Coll Med Biol & Environm, Canberra, ACT, Australia 7.Zeng, Q.] Chinese Acad Sci, Jiangsu Inst Bot, Nanjing Bot Garden, Nanjing 210014, Jiangsu, Peoples R China 8.[Zhu, C.; Ni, K.; Zhu, J.; Liu, G.] Chinese Acad Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, C.,Zeng, Q.,McMichael, A.,et al. Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide[J]. CLIMATIC CHANGE,2015,132(2):295-306. |
| APA | Zhu, C..,Zeng, Q..,McMichael, A..,Ebi, K. L..,Ni, K..,...&Ziska, L. H..(2015).Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide.CLIMATIC CHANGE,132(2),295-306. |
| MLA | Zhu, C.,et al."Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide".CLIMATIC CHANGE 132.2(2015):295-306. |
入库方式： OAI收割
来源：植物研究所
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