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In Search of Beneficial Coding RNA Editing

文献类型：期刊论文

作者Xu, Guixia; Zhang, Jianzhi1
刊名MOLECULAR BIOLOGY AND EVOLUTION
出版日期2015
卷号32期号:2页码:536-541
关键词editing level evolution human nonsynonymous
ISSN号0737-4038
DOI10.1093/molbev/msu314
文献子类Article
英文摘要RNA editing is a posttranscriptional modification that can lead to a change in the encoded protein sequence of a gene. Although a few cases of mammalian coding RNA editing are known to be functionally important, the vast majority of over 2,000 A-to-I editing sites that have been identified from the coding regions of the human genome are likely nonadaptive, representing tolerable promiscuous targeting of editing enzymes. Finding the potentially tiny fraction of beneficial editing sites from the sea of mostly nearly neutral editing is a difficult but important task. Here, we propose and provide evidence that evolutionarily conserved or hardwired residues that experience high-level nonsynonymous RNA editing in a species are enriched with beneficial editing. This simple approach allows the prediction of sites where RNA editing is functionally important. We suggest that priority be given to these candidates in future characterizations of the functional and fitness consequences of RNA editing.
学科主题Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
出版地OXFORD
电子版国际标准刊号1537-1719
WOS关键词ACCURATE IDENTIFICATION ; SEQUENCING DATA ; SEQ DATA ; SITES ; TRANSCRIPTOME ; DROSOPHILA ; TARGETS
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000350050700019
出版者OXFORD UNIV PRESS
资助机构US National Institutes of Health [R01GM103232] ; National Natural Science Foundation of China [31100170] ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM103232] Funding Source: NIH RePORTER
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/25840]  
专题植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文
作者单位1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China
2.Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714		 Xu, Guixia,Zhang, Jianzhi. In Search of Beneficial Coding RNA Editing[J]. MOLECULAR BIOLOGY AND EVOLUTION,2015,32(2):536-541.
APA Xu, Guixia,&Zhang, Jianzhi.(2015).In Search of Beneficial Coding RNA Editing.MOLECULAR BIOLOGY AND EVOLUTION,32(2),536-541.
MLA Xu, Guixia,et al."In Search of Beneficial Coding RNA Editing".MOLECULAR BIOLOGY AND EVOLUTION 32.2(2015):536-541.

入库方式： OAI收割

来源：植物研究所

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