O-linked beta-N-acetylglucosamine modification and its biological functions
文献类型：期刊论文
| 作者 | Liu, Yan1; Dai, Shaojun; Xing, Lijing1; Xu, Yunyuan1; Chong, Kang1 |
| 刊名 | SCIENCE BULLETIN
 |
| 出版日期 | 2015 |
| 卷号 | 60期号:12页码:1055-1061 |
| 关键词 | O-GlcNAc Posttranslational modification Epigenetic regulation Plants |
| ISSN号 | 2095-9273 |
| DOI | 10.1007/s11434-015-0816-x |
| 文献子类 | Review |
| 英文摘要 | The covalent attachment of O-linked beta-N-acetylglucosamine (O-GlcNAc) to Ser/Thr residues of proteins acts as not only a posttranslational modification but also a nutritional sensor in nucleus and cytoplasm, which directly regulates the expression of genes and multiple crucial signal transduction pathways. Dynamic O-GlcNAcylation at Ser/Thr residues is catalyzed by two key enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase, which are responsible for addition and removal of the O-GlcNAc modification, respectively. O-GlcNAc modification plays important roles in cellular signaling in animals, especially in human diseases. Two orthologs of OGT in plants, SECRET AGENT and SPINDLY, have been reported to be involved in diverse plant processes. However, compared with the functional mechanisms revealed in animals, the consequences of protein O-GlcNAc modification in plants is largely unknown, and the relationship between O-GlcNAcylation and cellular processes needs to be explored. In this review, we summarized the recent advances on O-GlcNAc modification and its biological functions in animals and plants, and prospect of more special functions of O-GlcNAc will be revealed in plants. |
| 学科主题 | Multidisciplinary Sciences |
| 出版地 | BEIJING |
| 电子版国际标准刊号 | 2095-9281 |
| WOS关键词 | POLYCOMB GROUP PROTEINS ; VIRUS CAPSID PROTEIN ; REPRESSIVE COMPLEX 2 ; GLCNAC TRANSFERASE ; SECRET-AGENT ; TETRATRICOPEPTIDE REPEATS ; STRESS-RESPONSE ; CARDIOVASCULAR-SYSTEM ; SUBSTRATE-SPECIFICITY ; CYTOSOLIC PROTEINS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000356538300001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/25577]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Northeast Forestry Univ, Alkali Soil Nat Environm Sci Ctr, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Minist Educ, Harbin 150040, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yan,Dai, Shaojun,Xing, Lijing,et al. O-linked beta-N-acetylglucosamine modification and its biological functions[J]. SCIENCE BULLETIN,2015,60(12):1055-1061. |
| APA | Liu, Yan,Dai, Shaojun,Xing, Lijing,Xu, Yunyuan,&Chong, Kang.(2015).O-linked beta-N-acetylglucosamine modification and its biological functions.SCIENCE BULLETIN,60(12),1055-1061. |
| MLA | Liu, Yan,et al."O-linked beta-N-acetylglucosamine modification and its biological functions".SCIENCE BULLETIN 60.12(2015):1055-1061. |
入库方式： OAI收割
来源：植物研究所
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