Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton
文献类型：期刊论文
| 作者 | Tian, Dong; Diao, Min1; Jiang, Yuxiang1; Sun, Lingfei; Zhang, Yan; Chen, Zhucheng; Huang, Shanjin1; Ou, Guangshuo |
| 刊名 | CURRENT BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:9页码:1135-1145 |
| ISSN号 | 0960-9822 |
| DOI | 10.1016/j.cub.2015.02.072 |
| 文献子类 | Article |
| 英文摘要 | Neuronal migration and neurite growth are essential events in neural development, but it remains unclear how guidance cues are transduced through receptors to the actin cytoskeleton, which powers these processes. We report that a cytokinetic scaffold protein, Anillin, is redistributed to the leading edge of the C. elegans Q neuroblast during cell migration and neurite growth. To bypass the requirement for Anillin in cytokinesis, we used the somatic CRISPR-Cas9 technique to generate conditional mutations in Anillin. We demonstrate that Anillin regulates cell migration and growth cone extension by stabilizing the F-actin network at the leading edge. Our biochemical analysis shows that the actin-binding domain of Anillin is sufficient to stabilize F-actin by antagonizing the F-actin severing activity of Cofilin. We further uncover that the active form of RhoG/MIG-2 directly binds to Anillin and recruits it to the leading edge. Our results reveal a novel pathway in which Anillin transduces the RhoG signal to the actin cytoskeleton during neuronal migration and neurite growth. |
| 学科主题 | Biochemistry & Molecular Biology ; Biology ; Cell Biology |
| 出版地 | CAMBRIDGE |
| 电子版国际标准刊号 | 1879-0445 |
| WOS关键词 | BINDING PROTEIN ANILLIN ; CAENORHABDITIS-ELEGANS ; C. ELEGANS ; CELL-MIGRATION ; CYTOKINESIS ; MYOSIN ; FILAMENTS ; COMPLEX ; ROLES ; STAGE |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000353999000020 |
| 出版者 | CELL PRESS |
| 资助机构 | National Basic Research Program of China (973 Program) [2013CB945600, 2012CB945002] ; National Natural Science Foundation of China [31222035, 31171295, 31190063, 31125004, 31270762] ; Junior Thousand Talents Program of China |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/25587]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Dong,Diao, Min,Jiang, Yuxiang,et al. Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton[J]. CURRENT BIOLOGY,2015,25(9):1135-1145. |
| APA | Tian, Dong.,Diao, Min.,Jiang, Yuxiang.,Sun, Lingfei.,Zhang, Yan.,...&Ou, Guangshuo.(2015).Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton.CURRENT BIOLOGY,25(9),1135-1145. |
| MLA | Tian, Dong,et al."Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton".CURRENT BIOLOGY 25.9(2015):1135-1145. |
入库方式： OAI收割
来源：植物研究所
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