Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species
文献类型：期刊论文
| 作者 | Yan, Shijuan; Liang, Yating; Zhang, Jindan; Chen, Zhuang; Liu, Chun-Ming
|
| 刊名 | FUNGAL GENETICS AND BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 81页码:229-237 |
| 关键词 | Linolenic acid Autoxidation Oxylipins Inhibition Aflatoxin production Aspergillus flavus |
| ISSN号 | 1087-1845 |
| DOI | 10.1016/j.fgb.2014.11.005 |
| 文献子类 | Article |
| 英文摘要 | Aflatoxins produced by Aspergillus species are among the most toxic and carcinogenic compounds in nature. Although it has been known for a long time that seeds with high oil content are more susceptible to aflatoxin contamination, the role of fatty acids in aflatoxin biosynthesis remains controversial. Here we demonstrate in A. flavus that both the saturated stearic acid (C18:0) and the polyunsaturated linolenic acid (C18:3) promoted aflatoxin production, while C18:3, but not C18:0, inhibited aflatoxin biosynthesis after exposure to air for several hours. Further experiments showed that autoxidated C18:3 promoted mycelial growth, sporulation, and kojic acid production, but inhibited the expression of genes in the AF biosynthetic gene cluster. Mass spectrometry analyses of autoxidated C18:3 fractions that were able to inhibit aflatoxin biosynthesis led to the identification of multiple oxylipin species. These results may help to clarify the role of fatty acids in aflatoxin biosynthesis, and may explain why controversial results have been obtained for fatty acids in the past. (C) 2014 Elsevier Inc. All rights reserved. |
| 学科主题 | Genetics & Heredity ; Mycology |
| 出版地 | SAN DIEGO |
| 电子版国际标准刊号 | 1096-0937 |
| WOS关键词 | FATTY-ACIDS ; MYCOTOXIN PRODUCTION ; B-1 PRODUCTION ; KOJIC ACID ; GROWTH ; PARASITICUS ; LIPIDS ; LIPOPEROXIDATION ; EXPRESSION |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000359885200024 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | CAS [KSCX2-YW-N-033] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/25707]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Shijuan,Liang, Yating,Zhang, Jindan,et al. Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species[J]. FUNGAL GENETICS AND BIOLOGY,2015,81:229-237. |
| APA | Yan, Shijuan,Liang, Yating,Zhang, Jindan,Chen, Zhuang,&Liu, Chun-Ming.(2015).Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species.FUNGAL GENETICS AND BIOLOGY,81,229-237. |
| MLA | Yan, Shijuan,et al."Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species".FUNGAL GENETICS AND BIOLOGY 81(2015):229-237. |
入库方式： OAI收割
来源：植物研究所
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