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PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1

文献类型：期刊论文

作者Mao, Juan1; Chi, Wei; Ouyang, Min; He, Baoye1; Chen, Fan2; Zhang, Lixin
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2015
卷号112期号:13页码:4152-4157
ISSN号0027-8424
关键词assembly ATP synthase chloroplast Cpn60
DOI10.1073/pnas.1413392111
文献子类Article
英文摘要The chloroplast ATP synthase, a multisubunit complex in the thylakoid membrane, catalyzes the light-driven synthesis of ATP, thereby supplying the energy for carbon fixation during photosynthesis. The chloroplast ATP synthase is composed of both nucleus-and chloroplast-encoded proteins that have required the evolution of novel mechanisms to coordinate the biosynthesis and assembly of chloroplast ATP synthase subunits temporally and spatially. Here we have elucidated the assembly mechanism of the alpha(3)beta(3)gamma core complex of the chloroplast ATP synthase by identification and functional characterization of a key assembly factor, PAB (PROTEIN IN CHLOROPLAST ATPASE BIOGENESIS). PAB directly interacts with the nucleus-encoded gamma subunit and functions downstream of chaperonin 60 (Cpn60)-mediated CF1 gamma subunit folding to promote its assembly into the catalytic core. PAB does not have any recognizable motifs or domains but is conserved in photosynthetic eukaryotes. It is likely that PAB evolved together with the transfer of chloroplast genes into the nucleus to assist nucleus-encoded CF1 gamma assembly into the CF1 core. Such coordination might represent an evolutionarily conserved mechanism for folding and assembly of nucleus-encoded proteins to ensure proper assembly of multiprotein photosynthetic complexes.
学科主题Multidisciplinary Sciences
出版地WASHINGTON
WOS关键词ARABIDOPSIS-THALIANA ; MOLECULAR CHAPERONES ; PHOTOSYSTEM-II ; IN-VIVO ; HEXADECAMERIC RUBISCO ; GENE-EXPRESSION ; GAMMA-SUBUNIT ; PROTEIN ; GROES ; PHOTOPHOSPHORYLATION
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
出版者NATL ACAD SCIENCES
WOS记录号WOS:000351914500083
资助机构National Natural Science Foundation of China [31130059] ; Major State Basic Research Development Program [2012CB917300] ; Solar Energy Initiative and Cooperative Team Project of the Chinese Academy of Sciences
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/25801]  
专题中科院光生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Bot, Photosynth Res Ctr, Key Lab Photobiol, Beijing 100093, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100086, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Juan,Chi, Wei,Ouyang, Min,et al. PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015,112(13):4152-4157.
APA Mao, Juan,Chi, Wei,Ouyang, Min,He, Baoye,Chen, Fan,&Zhang, Lixin.(2015).PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(13),4152-4157.
MLA Mao, Juan,et al."PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112.13(2015):4152-4157.

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来源：植物研究所

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