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Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species

文献类型：期刊论文

作者Li, Boqiang; Zong, Yuanyuan; Du, Zhenglin1; Chen, Yong; Zhang, Zhanquan; Qin, Guozheng; Zhao, Wenming1; Tian, Shiping
刊名MOLECULAR PLANT-MICROBE INTERACTIONS
出版日期2015
卷号28期号:6页码:635-647
ISSN号0894-0282
DOI10.1094/MPMI-12-14-0398-FI
文献子类Article
英文摘要Penicillium species are fungal pathogens that infect crop plants worldwide. P. expansum differs from P. italicum and P. digitatum, all major postharvest pathogens of pome and citrus, in that the former is able to produce the mycotoxin patulin and has a broader host range. The molecular basis of host-specificity of fungal pathogens has now become the focus of recent research. The present report provides the whole genome sequence of P. expansum (33.52 Mb) and P. italicum (28.99 Mb) and identifies differences in genome structure, important pathogenic characters, and secondary metabolite (SM) gene clusters in Penicillium species. We identified a total of 55 gene clusters potentially related to secondary metabolism, including a cluster of 15 genes (named PePatA to PePatO), that may be involved in patulin biosynthesis in P. expansum. Functional studies confirmed that PePatL and PePatK play crucial roles in the biosynthesis of patulin and that patulin production is not related to virulence of P. expansum. Collectively, P. expansum contains more pathogenic genes and SM gene clusters, in particular, an intact patulin cluster, than P. italicum or P. digitatum. These findings provide important information relevant to understanding the molecular network of patulin biosynthesis and mechanisms of host-specificity in Penicillium species.
学科主题Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Plant Sciences
出版地ST PAUL
电子版国际标准刊号1943-7706
WOS关键词CARBOHYDRATE-ACTIVE ENZYMES ; SECONDARY METABOLISM ; FILAMENTOUS FUNGI ; GENE-CLUSTER ; EXPANSUM ; ALIGNMENT ; ASPERGILLUS ; SEQUENCE ; DATABASE ; DIVERSIFICATION
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000356953600001
出版者AMER PHYTOPATHOLOGICAL SOC
资助机构National High Technology Research (863) Program of China [2012AA101607] ; National Natural Science Foundation of China [31030051] ; Chinese Academy of Sciences [KSCX2-EW-G-6]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/25862]  
专题中科院北方资源植物重点实验室
作者单位1.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing, Peoples R China
2.Chinese Acad Sci, Beijing Inst Genom, Core Genom Facil, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Boqiang,Zong, Yuanyuan,Du, Zhenglin,et al. Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species[J]. MOLECULAR PLANT-MICROBE INTERACTIONS,2015,28(6):635-647.
APA Li, Boqiang.,Zong, Yuanyuan.,Du, Zhenglin.,Chen, Yong.,Zhang, Zhanquan.,...&Tian, Shiping.(2015).Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species.MOLECULAR PLANT-MICROBE INTERACTIONS,28(6),635-647.
MLA Li, Boqiang,et al."Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species".MOLECULAR PLANT-MICROBE INTERACTIONS 28.6(2015):635-647.

入库方式： OAI收割

来源：植物研究所

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