“Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis
文献类型：期刊论文
| 作者 | Zhang,Jiaxin7,8; Ou,Ante6,7; Tang,Xueping5,7; Wang,Rong7; Fan,Yujuan3,4; Fang,Yuefei2; Zhao,Yuge7; Zhao,Pengfei4,7; Chen,Dongying3,4,6 ; Wang,Bing7,8
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| 刊名 | Journal of Nanobiotechnology
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| 出版日期 | 2022-08-30 |
| 卷号 | 20期号:1 |
| 关键词 | Ulcerative colitis Colonic drug delivery Patchouli alcohol Simvastatin Inflammatory microenvironment Anti-fibrosis |
| DOI | 10.1186/s12951-022-01598-0 |
| 通讯作者 | Wang,Bing(bwang@simm.ac.cn) ; Huang,Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | AbstractDysregulated mucosal immune responses and colonic fibrosis impose two formidable challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently deal with this complicated disease and combination therapy may provide a potential solution. A chitosan-modified poly(lactic-co-glycolic acid) nanoparticle (CS-PLGA NP) system was developed for co-delivering patchouli alcohol and simvastatin to the inflamed colonic epithelium to alleviate the symptoms of ulcerative colitis via remodeling immune microenvironment and anti-fibrosis, a so-called “two-birds-one-stone” nanotherapeutic strategy. The bioadhesive nanomedicine enhanced the intestinal epithelial cell uptake efficiency and improved the drug stability in the gastrointestinal tract. The nanomedicine effectively regulated the Akt/MAPK/NF-κB pathway and reshaped the immune microenvironment through repolarizing M2Φ, promoting regulatory T cells and G-MDSC, suppressing neutrophil and inflammatory monocyte infiltration, as well as inhibiting dendritic cell maturation. Additionally, the?nanomedicine alleviated colonic fibrosis. Our work elucidates that the colon-targeted codelivery for combination therapy is promising for ulcerative colitis treatment and to address the unmet medical need.Graphical Abstract |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12951-022-01598-0 |
| 出版者 | BioMed Central |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302038]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang,Bing; Huang,Yongzhuo |
| 作者单位 | 1.NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients 2.Zhongshan Institute for Drug Discovery, SIMM, CAS 3.Chinese Academy of Sciences; Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica 4.Nanjing University of Chinese Medicine; School of Chinese Materia Medica 5.Guangzhou University of Chinese Medicine; Artemisinin Research Center 6.University of Chinese Academy of Sciences 7.Chinese Academy of Sciences; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica 8.Shanghai University of Traditional Chinese Medicine; School of Pharmacy, Institute of Interdisciplinary Integrative Medicine Research |
| 推荐引用方式 GB/T 7714 | Zhang,Jiaxin,Ou,Ante,Tang,Xueping,et al. “Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis[J]. Journal of Nanobiotechnology,2022,20(1). |
| APA | Zhang,Jiaxin.,Ou,Ante.,Tang,Xueping.,Wang,Rong.,Fan,Yujuan.,...&Huang,Yongzhuo.(2022).“Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis.Journal of Nanobiotechnology,20(1). |
| MLA | Zhang,Jiaxin,et al."“Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis".Journal of Nanobiotechnology 20.1(2022). |
入库方式： OAI收割
来源：上海药物研究所
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