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Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health: A case-controlled study

文献类型：期刊论文

作者Duan, Yunfeng9; Wu, Xiaoli8,9; Yang, Yanan7; Gu, Liuqi1; Liu, Li6; Yang, Yunfeng5; Zhou, Jizhong3,4,5; Wu, Chongming2; Jin, Feng9
刊名INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
出版日期2022-09-01
卷号22期号:3页码:10
关键词Gut microbiota Mental disorders Neurotransmitter HuMiChip
ISSN号1697-2600
DOI10.1016/j.ijchp.2022.100323
通讯作者Wu, Chongming(chongmingwu@163.com)
英文摘要Background/Objective: The gut microbiota plays a pivotal role in psychological health, but the mechanistic perspective between gut microbiome and mental health remains poorly understood Method: The present case-controlled study recruited 30 unimprisoned subjects and 31 inmates that had been detained in jail for no more than a month. The mental health status, gut microbiota and blood NH3, H2S, 5-hydroxy trptamine and dopamine levels were measured. Results: Compared with unimprisoned controls, the fresh inmates exhibited significantly higher scores on anxiety and depression. Both phylogenetic structure and functional genes of the gut microbiota markedly shifted in inmates. Inmates was more Bacteroides-dominated, while unimprisoned subjects were more Prevotella-dominated. Short-chain fatty acids (SCFAs)-producing genera were largely decreased in inmates and were negatively related to mental disorder scores, while Bacteroidetes and Proteobacteria were positive to anxiety and depression scores. Simultaneously, the inmates possessed reduced genes that participate in amino acids, carbohy-drates and vitamin cofactors metabolism, but enriched genes that involved in the neurotransmit-ter-producing Shikimate pathway. Correlation analysis revealed that Anaerotruncus and Prevotella were negative to depression score, and Enterococcus was negative to anxiety score.Conclusions: Our results revealed potential link between gut microbiota and mental health, leading further support to the microbiota-gut-brain axis theory.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
收录类别SCI
资助项目China Postdoctoral Science Foundation[2013M541072] ; NS Bio Japan, Akita Japan
WOS研究方向Psychology
语种英语
WOS记录号WOS:000839413400002
出版者ELSEVIER SCIENCE INC
资助机构China Postdoctoral Science Foundation ; NS Bio Japan, Akita Japan
源URL[http://ir.psych.ac.cn/handle/311026/43276]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wu, Chongming
作者单位1.Cornell Univ, Dept Entomol, Geneva, NY USA
2.Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin, Peoples R China
3.Lawrence Berkeley Natl Lab, Earth Sci Div, Berkeley, CA USA
4.Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing, Peoples R China
5.Univ Oklahoma, Inst Environm Genom, Norman, OK 73019 USA
6.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing, Peoples R China
7.Chinese Acad Med Sci & Peking Union Med Coll, Pharmacol & Toxicol Res Ctr, Inst Med Plant Dev, Beijing, Peoples R China
8.Univ Chinese Acad Sci, Beijing, Peoples R China
9.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Duan, Yunfeng,Wu, Xiaoli,Yang, Yanan,et al. Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health: A case-controlled study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2022,22(3):10.
APA Duan, Yunfeng.,Wu, Xiaoli.,Yang, Yanan.,Gu, Liuqi.,Liu, Li.,...&Jin, Feng.(2022).Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health: A case-controlled study.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,22(3),10.
MLA Duan, Yunfeng,et al."Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health: A case-controlled study".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 22.3(2022):10.

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