痛觉与其它感觉模态刺激强度评分与脑激活一致性研究
文献类型：学位论文
| 作者 | 侯欣 |
| 答辩日期 | 2022-06 |
| 文献子类 | 硕士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 吕雪靖 |
| 关键词 | 疼痛矩阵 主成分分析 多模态 功能磁共振成像 |
| 学位名称 | 理学硕士 |
| 学位专业 | 应用心理 |
| 其他题名 | Consistency in behavior and brain activation between pain and other sensations |
| 中文摘要 | Nociceptive stimuli could induce activations in several brain regions, includingthe primary somatosensory cortex, secondary somatosensory cortex, thalamus, insula,and anterior cingulate cortex, as known as “pain matrix”. However, the so-called"pain matrix" might not be specific to pain, as a great part of these brain regions arealso activated in response to stimuli presented through other modalities, suggesting aconsistency across different modalities. To test this possibility, we examined thesimilarity of behavioral performance and brain activities in response to stimulidelivered through different modalities, using both behavioral and neuroimaging datafrom two datasets with 397 healthy subjects in total. In Study 1, correlation analyses were conducted separately for each dataset onthe subjective ratings of stimulus intensity across modalities (pain, touch, vision, andaudition). As expected, the intensity ratings of stimuli presented from differentmodalities were highly correlated. In addition, the results of principal componentanalysis further indicated that the behavioral ratings had a modality-shared componentand a pain-specific component. The findings demonstrated the modality-sharedcomponent might contribute to the similar brain activation patterns evoked bydifferent modalities and highlighted the possibility to separate the modality-sharedcomponent and the pain-specific component at the behavioral level. In Study 2, we evaluated brain responses evoked by nociceptive somatosensory,non-nociceptive somatosensory, auditory, and visual stimuli in two datasets, and thenexplored brain activations associated with first two behavioral components extractedin Study 1 using multiple regression analysis. The results showed that themodality-shared component was mainly associated with brain activations in saliencenetwork, including the anterior insula and anterior cingulate cortex, while thepain-specific component was mainly associated with brain activations in the medialdorsal nucleus and insula. These findings suggested that the similar brain activation patterns in different modalities might contribute to the salience of the stimulus. In Study 3, brain network co-activated in four modalities as wells as activated ineach modality were extracted using constrained principal component analysis. Theresults showed that the co-activated brain networks in four modalities included thesensorimotor network, frontoparietal network, salience network, pain matrix network,default network and visual network. Meanwhile, same brain networks were activatedin each modality, except for somatosensory network. The findings suggested thatdifferent modalities of stimulation could also evoked similar activations of brainnetwork. In summary, based on the stimulus-induced ratings and functional magneticimaging data from two datasets, this study systematically investigated the sharedmechanisms between nociceptive somatosensory, non-nociceptive somatosensory,auditory, and visual stimulation. This study verified the consistency of ratings andbrain activation patterns among modalities, and shed new insights into the sharedmechanisms from behavioral, brain activation, and brain network perspective. |
| 英文摘要 | 人体在接受痛觉刺激时会诱发包括初级躯体感觉皮层、次级躯体感觉皮层、丘脑、脑岛和前扣带皮层在内的“疼痛矩阵”脑区的激活。研究表明，“疼痛矩阵”脑区激活模式并非疼痛特异，触觉、听觉和视觉刺激诱发的脑激活模式与“疼痛矩阵”极为相似。针对以上现象，为了探究四模态刺激共同诱发的脑激活背后的脑机制，本研究以来自两个数据集的397名健康被试为研究对象，通过采集被试接受痛觉、触觉、听觉和视觉四种模态刺激的强度评分和功能磁共振成像数据，利用主成分分析方法分别从行为评分、脑激活和脑功能网络三个层面揭示多模态刺激的共性脑机制。 首先，研究一分别对两个数据集中被试的四模态感知觉刺激的强度评分进行相关分析，发现不同模态间的评分高度相关。此外，主成分分析结果显示行为评分存在共有成分和疼痛特异成分。以上研究结果表明不同模态刺激评分间存在显著的相关关系，这可能与不同模态脑区激活模式高度相似有关;从行为层面可能能够实现模态共有成分与疼痛特异成分的分离。 其次，研究二通过对被试在接受四种模态刺激时的功能磁共振数据进行分析，并使用多元回归分析对行为提取的成分进行脑激活的分析，分别探索了两个数据集中行为评分共有成分和疼痛特异成分相关的激活脑区。结果重复验证多模态刺激脑激活模式存在一致性的前人研究，显示共有成分主要与包括前脑岛和前扣带回皮层在内的凸显性网络脑区的激活有关，疼痛特异成分主要与丘脑背内侧核和脑岛等脑区的激活相关。以上研究结果提示四种模态刺激诱发的共有脑激活模式可能主要与凸显性网络有关，即与刺激的凸显性有关，且疼痛可能具有特异性激活脑区。 最后，研究三通过分别对两个数据集中四模态刺激下的功能磁共振成像进行约束主成分分析，提取四个模态共同激活的脑网络以及各模态单独激活的脑网络，从脑功能网络层面揭示四模态共性机制。结果显示，四模态共同激活的脑网络包括感觉运动网络、额顶和凸显网络、“疼痛矩阵”网络、默认网络和视觉网络，而各模态单独激活的脑网络中相同的脑网络包括感觉运动网络、额顶和凸显网络、“疼痛矩阵”网络、默认网络、视觉网络和躯体感觉网络。以上研究结果表明四模态共同激活以及各模态单独激活的脑网络均存在相似性。 综上所述，本研究基于两个大样本的四模态刺激下的行为学和功能磁共振数据，利用主成分分析方法，系统考察了痛觉、触觉、听觉和视觉刺激的强度评分与脑激活的共性机制。本研究验证了四种模态刺激诱发行为评分和脑激活模式的一致性，并从行为一局部脑功能一脑功能网络层面为分离四种模态共性成分和疼痛特异性成分提供了新视角。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43179]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 推荐引用方式 GB/T 7714 | 侯欣. 痛觉与其它感觉模态刺激强度评分与脑激活一致性研究[D]. 中国科学院心理研究所. 中国科学院大学. 2022. |
入库方式： OAI收割
来源：心理研究所
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