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Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping

文献类型：期刊论文

作者Feng, Chunliang1,11,12; Huang, Wenhao2,10; Xu, Kangli9; Camilleri, Julia A.6,7; Yang, Xiaofeng9; Wei, Ping10; Gu, Ruolei1,4,5; Luo, Wenbo3; Eickhoff, Simon B.6,7; Stewart, Jennifer L.8
刊名CLINICAL PSYCHOLOGY REVIEW
出版日期2022-08-01
卷号96页码:14
关键词Motivation Ventral striatum Meta -analysis Lesion network mapping Monetary incentive delay task
ISSN号0272-7358
DOI10.1016/j.cpr.2022.102189
通讯作者Feng, Chunliang(chunliang.feng@m.scnu.edu.cn) ; Gu, Ruolei(gurl@psych.ac.cn)
英文摘要Motivational dysfunction constitutes one of the fundamental dimensions of psychopathology cutting across traditional diagnostic boundaries. However, it is unclear whether there is a common neural circuit responsible for motivational dysfunction across neuropsychiatric conditions. To address this issue, the current study combined a meta-analysis on psychiatric neuroimaging studies of reward/loss anticipation and consumption (4308 foci, 438 contrasts, 129 publications) with a lesion network mapping approach (105 lesion cases). Our metaanalysis identified transdiagnostic hypoactivation in the ventral striatum (VS) for clinical/at-risk conditions compared to controls during the anticipation of both reward and loss. Moreover, the VS subserves a key node in a distributed brain network which encompasses heterogeneous lesion locations causing motivation-related symptoms. These findings do not only provide the first meta-analytic evidence of shared neural alternations linked to anticipatory motivation-related deficits, but also shed novel light on the role of VS dysfunction in motivational impairments in terms of both network integration and psychological functions. Particularly, the current findings suggest that motivational dysfunction across neuropsychiatric conditions is rooted in disruptions of a common brain network anchored in the VS, which contributes to motivational salience processing rather than encoding positive incentive values.
收录类别SCI
WOS关键词RESEARCH DOMAIN CRITERIA ; LIKELIHOOD ESTIMATION METAANALYSIS ; REWARD ANTICIPATION ; VENTRAL STRIATUM ; CIRCUIT DISRUPTIONS ; MAJOR DEPRESSION ; HUMAN BRAIN ; COMMON ; ACTIVATION ; PSYCHOPATHOLOGY
资助项目National Natural Science Foundation of China[31900757] ; National Natural Science Foundation of China[31971030] ; National Natural Science Foundation of China[32071083] ; National Natural Science Foundation of China[32020103008] ; Natural Science Foundation of Guangdong Province[2021A1515010746] ; Major Program of the Chinese National Social Science Foundation[17ZDA324] ; Youth Innovation Promotion Association, CAS[2019088] ; National Institute of Mental Health[R01-MH074457] ; European Union[785907]
WOS研究方向Psychology
语种英语
WOS记录号WOS:000841261000002
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Major Program of the Chinese National Social Science Foundation ; Youth Innovation Promotion Association, CAS ; National Institute of Mental Health ; European Union
源URL[http://ir.psych.ac.cn/handle/311026/43241]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Feng, Chunliang; Gu, Ruolei
作者单位1.South China Normal Univ, Ctr Studies Psychol Applicat, Sch Psychol, Guangdong Prov Key Lab Mental Hlth & Cognit Sci, Guangzhou 510631, Peoples R China
2.German Inst Human Nutr Potsdam Rehbrucke, Dept Decis Neurosci & Nutr, Potsdam, Germany
3.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian 100101, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
6.Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM-7, Julich, Germany
7.Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, Med Fac, Dusseldorf, Germany
8.Laureate Inst Brain Res, Tulsa, OK USA
9.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou, Zhejiang, Peoples R China
10.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Chunliang,Huang, Wenhao,Xu, Kangli,et al. Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping[J]. CLINICAL PSYCHOLOGY REVIEW,2022,96:14.
APA Feng, Chunliang.,Huang, Wenhao.,Xu, Kangli.,Camilleri, Julia A..,Yang, Xiaofeng.,...&Stewart, Jennifer L..(2022).Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping.CLINICAL PSYCHOLOGY REVIEW,96,14.
MLA Feng, Chunliang,et al."Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping".CLINICAL PSYCHOLOGY REVIEW 96(2022):14.

入库方式： OAI收割

来源：心理研究所

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