Cu,Zn Dopants Boost Electron Transfer of Carbon Dots for Antioxidation
文献类型：期刊论文
| 作者 | BSRF用户 |
| 刊名 | SMALL
 |
| 出版日期 | 2021 |
| 卷号 | 17期号:31页码:2102178 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202102178 |
| 文献子类 | Article |
| 英文摘要 | Enzyme-mimicking nanomaterials for antioxidative therapy is a promising star to treat more than 200 diseases or control their progressions through scavenging excessive reactive oxygen species (ROS), such as O-2(center dot-) and H2O2. However, they can inversely produce stronger ROS (e.g., center dot OH) under many disease conditions (e.g., low pH for myocardial ischemia). Herein, a biocompatible -Cu-O-Zn- bimetallic covalent doped carbon dots (CuZn-CDs) processing both catalase (CAT) and superoxide dismutase activities are reported, mainly because of their abundant electrons and the excellent electron transfer abilities. In addition, Cu dopant helps to balance the positive charge at Zn dopant resulting from low pH, enabling CuZn-CDs to still process CAT ability rather than peroxidase ability. Benefiting from it, CuZn-CDs exhibit sufficient in vitro ROS scavenging ability and cardiomyocyte protective effect against ROS-induced damage. In vivo results further demonstrate that CuZn-CDs can protect the heart from ischemia-reperfusion injury. In addition to antioxidative therapy, the rapid renal clearance and low toxicity properties of CuZn-CDs in animal model reveal high biocompatibility which will facilitate clinical use. |
| 电子版国际标准刊号 | 1613-6829 |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000668521600001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/293112]  |
| 专题 | 北京同步辐射装置 |
| 推荐引用方式 GB/T 7714 | BSRF用户. Cu,Zn Dopants Boost Electron Transfer of Carbon Dots for Antioxidation[J]. SMALL,2021,17(31):2102178. |
| APA | BSRF用户.(2021).Cu,Zn Dopants Boost Electron Transfer of Carbon Dots for Antioxidation.SMALL,17(31),2102178. |
| MLA | BSRF用户."Cu,Zn Dopants Boost Electron Transfer of Carbon Dots for Antioxidation".SMALL 17.31(2021):2102178. |
入库方式： OAI收割
来源：高能物理研究所
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