MALDI-TOF-MS and XAS analysis of complexes formed by metallothionein with mercury and/or selenium
文献类型：期刊论文
| 作者 | BSRF用户 |
| 刊名 | BIOMETALS
 |
| 出版日期 | 2021 |
| 卷号 | 34期号:6页码:1353--1363 |
| ISSN号 | 0966-0844 |
| DOI | 10.1007/s10534-021-00346-5 |
| 文献子类 | Article |
| 英文摘要 | Mercury (Hg) is highly toxic while selenium (Se) has been found to antagonize Hg. Both Hg and Se have been found to induce metallothioneins (MTs). In this study, the complexes formed by metallothionein-1 (MT-1) with HgCl2 and/or Na2SeO3 was studied using matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) and X-ray absorption spectrometry (XAS). MALDI-TOF-MS and XAS indicated the formation of Hg-S bond or Se-S bond when MT-1 reacted with HgCl2 or Na2SeO3, respectively. The bond lengths of Hg-S and coordination number in MT-Hg are 2.41 +/- 0.02 angstrom and 3.10 and in MT-Se are 2.50 +/- 0.03 angstrom and 2.69. A MT-Se-Hg complex was formed when MT-1 reacted with both HgCl2 and Na2SeO3, in which the neighboring atom of Hg is Se, while the neighboring atoms of Se are S and Hg. Our study is an important step towards a better understanding of the interaction of HgCl2 and/or Na2SeO3 with proteins like MT-1. |
| 电子版国际标准刊号 | 1572-8773 |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000702796800002 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/293236]  |
| 专题 | 北京同步辐射装置 |
| 推荐引用方式 GB/T 7714 | BSRF用户. MALDI-TOF-MS and XAS analysis of complexes formed by metallothionein with mercury and/or selenium[J]. BIOMETALS,2021,34(6):1353--1363. |
| APA | BSRF用户.(2021).MALDI-TOF-MS and XAS analysis of complexes formed by metallothionein with mercury and/or selenium.BIOMETALS,34(6),1353--1363. |
| MLA | BSRF用户."MALDI-TOF-MS and XAS analysis of complexes formed by metallothionein with mercury and/or selenium".BIOMETALS 34.6(2021):1353--1363. |
入库方式： OAI收割
来源：高能物理研究所
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