Multiscale Synchrotron-Based Imaging Analysis for the Transfer of PEGylated Gold Nanoparticles In Vivo
文献类型：期刊论文
| 作者 | BSRF用户 |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2021 |
| 卷号 | 7期号:4页码:1462--1474 |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.0c01764 |
| 文献子类 | Article |
| 英文摘要 | High spatial resolution imaging analysis is urgently needed to explore the biodistribution, transfer and clearance profiles, and biological impact of nanoparticles in the body, which will be helpful to clarify the efficacy of nanomedicine in clinical applications. Herein, by combination with multiscale synchrotron-based imaging techniques, including X-ray fluorescence (XRF) spectrometry, Fourier transform infrared (FTIR) spectroscopy, and micro X-ray phase contrast computed tomography (microXPCT), we visually displayed the transfer patterns and site-specific distribution of PEGylated gold nanoparticles (PEG-GNPs) in the suborgans of the liver, spleen, and kidney after an intravenous injection in mice. A combination of XRF and FTIR imaging analysis showed that the PEG bands presented similar distribution patterns with Au in the intraorgans, suggesting the stability of PEGylation on GNPs. We show that the PEG-GNPs presented heterogeneous distribution in the hepatic lobules with a large amount around the portal vein zone and then a gradient decrease in the sinusoidal region and the CV zone; in the spleen, it gradually accumulated in the splenic red pulp over time; and in the kidney, it quickly transported via the bloodstream to the renal pyramids and renal pelvis, and parts of PEG-GNPs finally accumulated in the renal medulla and renal cortex. Multidimensional micro-XPCT images further show that the PEG-GNP transfer in the liver induced hepatic blood vessel dilatation while they transferred in the liver, providing evidence of GNP transport across the blood vessel endothelial barrier. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000640306300013 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/293260]  |
| 专题 | 北京同步辐射装置 |
| 推荐引用方式 GB/T 7714 | BSRF用户. Multiscale Synchrotron-Based Imaging Analysis for the Transfer of PEGylated Gold Nanoparticles In Vivo[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2021,7(4):1462--1474. |
| APA | BSRF用户.(2021).Multiscale Synchrotron-Based Imaging Analysis for the Transfer of PEGylated Gold Nanoparticles In Vivo.ACS BIOMATERIALS SCIENCE & ENGINEERING,7(4),1462--1474. |
| MLA | BSRF用户."Multiscale Synchrotron-Based Imaging Analysis for the Transfer of PEGylated Gold Nanoparticles In Vivo".ACS BIOMATERIALS SCIENCE & ENGINEERING 7.4(2021):1462--1474. |
入库方式： OAI收割
来源：高能物理研究所
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