In vitro and in vivo studies on bacteria and encrustation resistance of heparin/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application
文献类型：期刊论文
| 作者 | Awonusi, Bukola O.2,3; Li, Jianzhong1; Li, Hongwei1; Wang, Zhenyu1; Yang, Ke3; Zhao, Jing3 |
| 刊名 | REGENERATIVE BIOMATERIALS
 |
| 出版日期 | 2022-04-08 |
| 卷号 | 9页码:11 |
| 关键词 | ureteral stents nanoparticles biofilm encrustation |
| ISSN号 | 2056-3418 |
| DOI | 10.1093/rb/rbac047 |
| 通讯作者 | Yang, Ke(kyang@imr.ac.cn) ; Zhao, Jing(zhaojing@imr.ac.cn) |
| 英文摘要 | Ureteral stents are commonly utilized as a medical device to aid the flow of urine. However, biofilm formation and encrustation complications have been clinical problems. To overcome this challenge, heparin/poly-L-lysine-copper (Hep/PLL-Cu) nanoparticle was immobilized on a dopamine-coated polyurethane surface (PU/NPs). The stability and structural properties of the nanoparticles were characterized by Zeta potential, poly dispersion index, transmission electron microscopy, atom force microscopy and contact angle. The surface composition, antibacterial potency, encrustation resistance rate and biocompatibility of PU/NPs were investigated by scanning electron microscope, X-ray photoelectron spectroscopy, antibacterial assay and MTS assay, respectively. In addition, the anti-encrustation property was studied by implanting coated NPs stents in the rat bladder for 7 days. It was shown that the size and distribution of Hep/PLL-Cu nanoparticles were uniform. PU/NPs could inhibit Proteus mirabilis proliferation and biofilm formation, and exhibit no cytotoxicity. Less encrustation (Ca and Mg salt) was deposited both in vitro and in vivo on samples, demonstrating that the NPs coating could be a potential surface modification method of ureteral material for clinical use. |
| 资助项目 | Liaoning Science and Technology Program[2020JH2/10300159] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000835421500004 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | Liaoning Science and Technology Program |
| 源URL | [http://ir.imr.ac.cn/handle/321006/174623]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Yang, Ke; Zhao, Jing |
| 作者单位 | 1.Gen Hosp Northern Theater Command, Dept Urol, Shenyang 110840, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 3.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Awonusi, Bukola O.,Li, Jianzhong,Li, Hongwei,et al. In vitro and in vivo studies on bacteria and encrustation resistance of heparin/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application[J]. REGENERATIVE BIOMATERIALS,2022,9:11. |
| APA | Awonusi, Bukola O.,Li, Jianzhong,Li, Hongwei,Wang, Zhenyu,Yang, Ke,&Zhao, Jing.(2022).In vitro and in vivo studies on bacteria and encrustation resistance of heparin/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application.REGENERATIVE BIOMATERIALS,9,11. |
| MLA | Awonusi, Bukola O.,et al."In vitro and in vivo studies on bacteria and encrustation resistance of heparin/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application".REGENERATIVE BIOMATERIALS 9(2022):11. |
入库方式： OAI收割
来源：金属研究所
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