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Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function

文献类型：期刊论文

作者Yan, Yangyang3,4; Li, Na2; Guo, Feng3,4; Wu, Anhua1; Jin, Wei3,4; Yang, Rui3,4; Bai, Yun3,4; Zhang, Xing3,4
刊名ACTA METALLURGICA SINICA-ENGLISH LETTERS
出版日期2022-07-03
页码13
关键词Nitinol stents Conformability Radial force Endothelialization Intracranial stenosis treatment
ISSN号1006-7191
DOI10.1007/s40195-022-01435-1
通讯作者Bai, Yun(ybai@imr.ac.cn) ; Zhang, Xing(xingzhang@imr.ac.cn)
英文摘要Intracranial vascular stenting has been widely used for ischemic stroke. However, there are complication risks with stent implantation, such as poor wall apposition, stent migration, thromboembolism and stent restenosis, due to the mismatched radial force and conformability of the stents. Therefore, a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization function. The bending moment of the stents was calculated to be 0.346 N mm, which shows improved conformability. The radial force of the stents evaluated by the flat plate test was 0.0112 N/mm, within the range of the commercially available stent force (0.0065-0.0116 N/mm). Furthermore, the Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation, adhesion and migration of human umbilical vein endothelial cells in vitro. The nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation.
资助项目National Key Research and Development program[2018YFC1105503]
WOS研究方向Metallurgy & Metallurgical Engineering
语种英语
WOS记录号WOS:000820119600001
出版者CHINESE ACAD SCIENCES, INST METAL RESEARCH
资助机构National Key Research and Development program
源URL[http://ir.imr.ac.cn/handle/321006/174889]  
专题金属研究所_中国科学院金属研究所
通讯作者Bai, Yun; Zhang, Xing
作者单位1.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China
2.Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China
3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
4.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Yangyang,Li, Na,Guo, Feng,et al. Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2022:13.
APA Yan, Yangyang.,Li, Na.,Guo, Feng.,Wu, Anhua.,Jin, Wei.,...&Zhang, Xing.(2022).Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function.ACTA METALLURGICA SINICA-ENGLISH LETTERS,13.
MLA Yan, Yangyang,et al."Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2022):13.

入库方式： OAI收割

来源：金属研究所

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