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Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort

文献类型：期刊论文

作者Ge, Erjia3; Gao, Jianhui3; Wei, Xiaolin3; Ren, Zhoupeng2; Wei, Jing1; Liu, Xin4; Wang, Xiaomeng5; Zhong, Jieming5; Lu, Jingru6; Tian, Xiaomei6
刊名THORAX
出版日期2021-12-06
页码8
ISSN号0040-6376
关键词tuberculosis
DOI10.1136/thoraxjnl-2020-216819
通讯作者Peng, Ying(ypeng@cdc.zj.cn) ; Luo, Ming(luom38@mail.sysu.edu.cn) ; Lei, Juan(leijuan.316@163.com)
英文摘要Rationale Evidence for the association between fine particulate matter (PM2.5) and mortality among patients with tuberculosis (TB) is limited. Whether greenness protects air pollution-related mortality among patients with multidrug-resistant tuberculosis (MDR-TB) is completely unknown. Methods 2305 patients reported in Zhejiang and Ningxia were followed up from MDR-TB diagnosis until death, loss to follow-up or end of the study (31 December 2019), with an average follow-up of 1724 days per patient. 16-day averages of contemporaneous Normalised Difference Vegetation Index (NDVI) in the 500 m buffer of patient's residence, annual average PM2.5 and estimated oxidant capacity O-x were assigned to patients regarding their geocoded home addresses. Cox proportional hazards regression models were used to estimate HRs per 10 mu g/m(3) exposure to PM2.5 and all-cause mortality among the cohort and individuals across the three tertiles, adjusting for potential covariates. Results HRs of 1.702 (95% CI 1.680 to 1.725) and 1.169 (1.162 to 1.175) were observed for PM2.5 associated with mortality for the full cohort and individuals with the greatest tertile of NDVI. Exposures to PM2.5 were stronger in association with mortality for younger patients (HR 2.434 (2.432 to 2.435)), female (2.209 (1.874 to 2.845)), patients in rural (1.780 (1.731 to 1.829)) and from Ningxia (1.221 (1.078 to 1.385)). Cumulative exposures increased the HRs of PM2.5-related mortality, while greater greenness flattened the risk with HRs reduced in 0.188-0.194 on average. Conclusions Individuals with MDR-TB could benefit from greenness by having attenuated associations between PM2.5 and mortality. Improving greener space and air quality may contribute to lower the risk of mortality from TB/MDR-TB and other diseases.
WOS关键词AMBIENT AIR-POLLUTION ; MYCOBACTERIUM-TUBERCULOSIS ; RESIDENTIAL GREENNESS ; CHINA ; TRANSMISSION ; EXPOSURE ; OZONE ; MODEL ; TB
资助项目National Health Commission of China-Bill & Melinda Gates Foundation TB Project[OPP1137180] ; Natural Science Foundation of Ningxia[NZ17219] ; Zhejiang Provincial Medical and Health Project[2019RC135] ; State Key Laboratory of Health Technology Assessment, Fudan University[FHTA2019-05] ; National Nature Science Foundation of China[71640019] ; Pearl River Talent Recruitment Program of Guangdong Province[2017GC010634]
WOS研究方向Respiratory System
语种英语
出版者BMJ PUBLISHING GROUP
WOS记录号WOS:000728271500001
资助机构National Health Commission of China-Bill & Melinda Gates Foundation TB Project ; Natural Science Foundation of Ningxia ; Zhejiang Provincial Medical and Health Project ; State Key Laboratory of Health Technology Assessment, Fudan University ; National Nature Science Foundation of China ; Pearl River Talent Recruitment Program of Guangdong Province
源URL[http://ir.igsnrr.ac.cn/handle/311030/168444]  
专题中国科学院地理科学与资源研究所
通讯作者Peng, Ying; Luo, Ming; Lei, Juan
作者单位1.Univ Iowa, Iowa Technol Inst, Dept Chem & Biochem Engn, Iowa City, IA USA
2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China
3.Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
4.Southwest Petr Univ, Sch Geosci & Technol, Chengdu, Sichuan, Peoples R China
5.Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China
6.Fourth Peoples Hosp Ningxia, Inst Ningxia TB Control, Yinchuan, Ningxia, Peoples R China
7.Sun Yat Sen Univ, Sch Geog & Planning, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Ge, Erjia,Gao, Jianhui,Wei, Xiaolin,et al. Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort[J]. THORAX,2021:8.
APA Ge, Erjia.,Gao, Jianhui.,Wei, Xiaolin.,Ren, Zhoupeng.,Wei, Jing.,...&Lei, Juan.(2021).Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort.THORAX,8.
MLA Ge, Erjia,et al."Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort".THORAX (2021):8.

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来源：地理科学与资源研究所

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