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Whole-body chemical imaging of Cordyceps sinensis by TOF-SIMS to visualize spatial differentiation of ergosterol and other active components

文献类型：期刊论文

作者Xia, Meng-Chan3; Cai, Lesi4,5; Xu, Fujian1; Zhan, Qin2; Feng, Jiaxin5; Guo, Chong5,6; Li, Qin5,6; Li, Zhanping5,6
刊名MICROCHEMICAL JOURNAL
出版日期2022-06-01
卷号177页码:9
关键词Whole-body chemical imaging Cordyceps sinensis Ergosterol Active components TOF-SIMS
ISSN号0026-265X
DOI10.1016/j.microc.2022.107303
通讯作者Cai, Lesi(Cails92@126.com) ; Li, Zhanping(zhanpingli@mail.tsinghua.edu.cn)
英文摘要Analysis of active components in Cordyceps sinensis (C. sinensis) is emerging as a research hotspot in traditional Chinese medicine. Here, the visualization of spatial differentiation of ergosterol and other active components in whole C. sinensis was first realized by developing a feasible and simple "segmentation-imaging-splicing" strategy based on time-of-flight secondary ion mass spectrometry (TOF-SIMS). A C. sinensis was divided into four parts for TOF-SIMS ion imaging due to its irregular shape and centimeter-scale longitudinal length. Whole-body chemical mapping of C. sinensis was then accomplished by splicing these ion images with normalized size and signal in-tensity. Specifically, ergosterol was found more enriched in host caterpillar, especially enriched in the top of host caterpillar, than in fruiting body. Moreover, ergosterol and lipids showed obviously complementary distribution pattern in some special structures of C. sinensis. This panoramic scanning strategy could provide abundant in-formation about the macroscopic and microscopic spatial differentiation of active components in whole C. sinensis, facilitating the realization of multi-component analysis. The results are expected to give further insight into the growth process of C. sinensis in a new vision and promote the development of extraction tech-nologies for active ingredients in C. sinensis.
WOS关键词METABOLOMICS METHOD ; QUALITY-CONTROL ; SPECTROMETRY
资助项目National Key R&D Program of China[2018YFA0702600] ; National Natural Science Foundation of China[21727813] ; National Natural Science Foundation of China[21974078]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000793721700001
出版者ELSEVIER
资助机构National Key R&D Program of China ; National Natural Science Foundation of China
源URL[http://ir.igsnrr.ac.cn/handle/311030/176345]  
专题中国科学院地理科学与资源研究所
通讯作者Cai, Lesi; Li, Zhanping
作者单位1.Southwest Minzu Univ, Sch Chem & Environm, Chengdu 610041, Peoples R China
2.China Univ Min & Technol, Sch Chem & Environm Engn, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
4.Beijing Narcot Control Technol Ctr, Beijing 100164, Peoples R China
5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
6.Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714		 Xia, Meng-Chan,Cai, Lesi,Xu, Fujian,et al. Whole-body chemical imaging of Cordyceps sinensis by TOF-SIMS to visualize spatial differentiation of ergosterol and other active components[J]. MICROCHEMICAL JOURNAL,2022,177:9.
APA Xia, Meng-Chan.,Cai, Lesi.,Xu, Fujian.,Zhan, Qin.,Feng, Jiaxin.,...&Li, Zhanping.(2022).Whole-body chemical imaging of Cordyceps sinensis by TOF-SIMS to visualize spatial differentiation of ergosterol and other active components.MICROCHEMICAL JOURNAL,177,9.
MLA Xia, Meng-Chan,et al."Whole-body chemical imaging of Cordyceps sinensis by TOF-SIMS to visualize spatial differentiation of ergosterol and other active components".MICROCHEMICAL JOURNAL 177(2022):9.

入库方式： OAI收割

来源：地理科学与资源研究所

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