Gestational PM2.5 exposure may increase the risk of small for gestational age through maternal blood pressure and hemoglobin: A mediation analysis based on a prospective cohort in China, 2014-2018
文献类型：期刊论文
| 作者 | Zhu, Zhenghong2; Hu, Huanqing3; Benmarhnia, Tarik4,5; Ren, Zhoupeng6; Luo, Jiajun7; Zhao, Wei3; Chen, Sidi3; Wu, Kaipu2; Zhang, Xiaoxin2; Wang, Liyun2 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2022-09-01 |
| 卷号 | 242页码:8 |
| ISSN号 | 0147-6513 |
| 关键词 | PM2.5 Mediation analysis SGA Blood pressure Hemoglobin |
| DOI | 10.1016/j.ecoenv.2022.113836 |
| 通讯作者 | Di, Jiangli(dijiangli@chinawch.org.cn) ; Wang, Qiong(wangqiong@mail.sysu.edu.cn) |
| 英文摘要 | Background: Maternal gestational PM2.5 exposure was associated with small for gestational age (SGA). Identifying potential mediating factors may help design preventive strategies to reduce this risk. Objective: This study aimed to explore the roles of maternal blood pressure and hemoglobin may play in the PM2.5 exposure and SGA relationship among 117,162 births in 16 counties across China during 2014-2018. Methods: Daily PM2.5 concentration was collected from China National Environmental Monitoring Center. Ac-cording to maternal residency during pregnancy, the PM2.5 exposure for each trimester and the whole pregnancy was assessed using an inverse-distance weighting approach. Repeated measurements of maternal blood pressure and hemoglobin during pregnancy were collected for each woman. We estimated the total effect of gestational PM2.5 exposure on SGA, and further tested the mediation effects of maternal blood pressure and hemoglobin concentration during pregnancy. Results: Of 117,162 included mother-infant pairs, 11,361 (9.7 %) were SGA. The odds ratios of SGA associated with PM(2.5 )exposure (per 10 mu g/m(3) increase) in the second trimester and the whole pregnancy were 1.023 (95 % CI: 1.009, 1.037) and 1.024 (1.001, 1.048), respectively. We identified the independent mediating effect of blood pressure and hemoglobin in the second and third trimesters, with the proportion of mediation ranging from 1.64 % to 5.78 % and 2.40 % to 8.70 %, respectively. When considering the mediators jointly, we found a stronger mediating effect with a proportion of mediation ranging from 3.93 % to 13.69 %. Discussion: Increases in maternal blood pressure and hemoglobin in the second and third trimesters can inde-pendently and jointly mediate the effects of gestational PM2.5 exposure on SGA. Monitoring and managing maternal blood pressure and hemoglobin during prenatal care may constitute a promising avenue to reducing SGA risk associated with gestational PM2.5 exposure. |
| WOS关键词 | 3RD TRIMESTER HEMOGLOBIN ; AIR-POLLUTION EXPOSURE ; PREGNANCY OUTCOMES ; FETAL-GROWTH ; CARDIOVASCULAR-DISEASE ; BIRTH OUTCOMES ; PREECLAMPSIA ; ASSOCIATIONS ; DELIVERY ; WEIGHT |
| 资助项目 | National Natural Sci-ence Foundation of China[42075178] ; National Key Research and Development Program of China[2018YFA0606200] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515011947] ; Guangzhou Basic and Applied Basic Research Foundation[202102020408] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000829845100006 |
| 资助机构 | National Natural Sci-ence Foundation of China ; National Key Research and Development Program of China ; Guangdong Basic and Applied Basic Research Foundation ; Guangzhou Basic and Applied Basic Research Foundation |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/181223]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Di, Jiangli; Wang, Qiong |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent, Natl Ctr Women & Childrens Hlth, 12 Dahuisi Rd, Beijing 100081, Peoples R China 2.Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Peoples R China 3.Chinese Ctr Dis Control & Prevent, Natl Ctr Women & Childrens Hlth, Beijing, Peoples R China 4.Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA USA 5.Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA USA 6.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China 7.Univ Chicago, Inst Populat & Precis Hlth, Chicago, IL USA 8.Tsinghua Univ, Wanke Sch Publ Hlth, Beijing, Peoples R China 9.Sun Yat Sen Univ, Sch Publ Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Zhenghong,Hu, Huanqing,Benmarhnia, Tarik,et al. Gestational PM2.5 exposure may increase the risk of small for gestational age through maternal blood pressure and hemoglobin: A mediation analysis based on a prospective cohort in China, 2014-2018[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,242:8. |
| APA | Zhu, Zhenghong.,Hu, Huanqing.,Benmarhnia, Tarik.,Ren, Zhoupeng.,Luo, Jiajun.,...&Wang, Qiong.(2022).Gestational PM2.5 exposure may increase the risk of small for gestational age through maternal blood pressure and hemoglobin: A mediation analysis based on a prospective cohort in China, 2014-2018.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,242,8. |
| MLA | Zhu, Zhenghong,et al."Gestational PM2.5 exposure may increase the risk of small for gestational age through maternal blood pressure and hemoglobin: A mediation analysis based on a prospective cohort in China, 2014-2018".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 242(2022):8. |
入库方式： OAI收割
来源：地理科学与资源研究所
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