Facile synthesis of biocompatible magnetic titania nanorods for T-1-magnetic resonance imaging and enhanced phototherapy of cancers
文献类型：期刊论文
| 作者 | Iqbal, M. Zubair; Luo, Dandan; Akakuru, Ozioma U.; Mushtaq, Asim; Hou, Yike; Ali, Israt; Ijaz, Gohar; Khalid, Bilal; Kong, Xiangdong; Wu, Aiguo |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2021 |
| 卷号 | 9期号:33页码:6623-6633 |
| 关键词 | IRON-OXIDE NANOPARTICLES CONTRAST AGENTS MANGANESE CELLS IONS |
| 英文摘要 | Cancer treatment has been recently energized by nanomaterials that simultaneously offer diagnostic and therapeutic effects. Among the imaging and treatment modalities in frontline research today, magnetic resonance imaging (MRI) and phototherapy have gained significant interest due to their noninvasiveness among other intriguing benefits. Herein, Fe(iii) was adsorbed on titanium dioxide to develop magnetic Fe-TiO2 nanocomposites (NCs) which leverage the Fe moiety in a double-edge-sword approach to: (i) achieve T-1-weighted MRI contrast enhancement, and (ii) improve the well-established photodynamic therapeutic efficacy of TiO2 nanoparticles. Interestingly, the proposed NCs exhibit classic T-1 MRI contrast agent properties (r(1) = 1.16 mM(-1) s(-1)) that are comparable to those of clinically available contrast agents. Moreover, the NCs induce negligible cytotoxicity in traditional methods and show remarkable support to the proliferation of intestine organoids, an advanced toxicity evaluation system based on three-dimensional organoids, which could benefit their potential safe application for in vivo cancer theranostics. Aided by the Fenton reaction contribution of the Fe component of the Fe-TiO2 NCs, considerable photo-killing of cancer cells is achieved upon UV irradiation at very low (2.5 mW cm(-2)) intensity in typical cancer PDT. It is therefore expected that this study will guide the engineering of other biocompatible magnetic titania-based nanosystems with multi-faceted properties for biomedical applications. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21664]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Kong, XD (corresponding author), Zhejiang Sci Tech Univ, Inst Smart Biomed Mat, Sch Mat Sci & Engn, Hangzhou 310018, Peoples R China. 2.Wu, AG (corresponding author), Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Chinese Acad Sci, Key Lab Magnet Mat & Devices, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Iqbal, M. Zubair,Luo, Dandan,Akakuru, Ozioma U.,et al. Facile synthesis of biocompatible magnetic titania nanorods for T-1-magnetic resonance imaging and enhanced phototherapy of cancers[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(33):6623-6633. |
| APA | Iqbal, M. Zubair.,Luo, Dandan.,Akakuru, Ozioma U..,Mushtaq, Asim.,Hou, Yike.,...&Wu, Aiguo.(2021).Facile synthesis of biocompatible magnetic titania nanorods for T-1-magnetic resonance imaging and enhanced phototherapy of cancers.JOURNAL OF MATERIALS CHEMISTRY B,9(33),6623-6633. |
| MLA | Iqbal, M. Zubair,et al."Facile synthesis of biocompatible magnetic titania nanorods for T-1-magnetic resonance imaging and enhanced phototherapy of cancers".JOURNAL OF MATERIALS CHEMISTRY B 9.33(2021):6623-6633. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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