Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ss-Elemene for Cancer Therapy
文献类型：期刊论文
| 作者 | Liu, Chuang; Sun, Shan; Feng, Qiang; Wu, Gongwei; Wu, Yiting; Kong, Na; Yu, Zhangsen; Yao, Junlie; Zhang, Xingcai; Chen, Wei |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2021 |
| 卷号 | 33期号:37 |
| 关键词 | ACUTE PROMYELOCYTIC LEUKEMIA BETA-ELEMENE DELIVERY PHOSPHORUS PNICTOGENS CHEMISTRY TRIOXIDE |
| 英文摘要 | Arsenical drugs have achieved hallmark success in treating patients with acute promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult with the contradiction between the therapeutic efficacy and the systemic toxicity. Here, leveraging efforts from materials science, biocompatible PEGylated arsenene nanodots (AsNDs@PEG) with high monoelemental arsenic purity that can selectively and effectively treat solid tumors are synthesized. The intrinsic selective killing effect of AsNDs@PEG is closely related to high oxidative stress in tumor cells, which leads to an activated valence-change of arsenic (from less toxic As-0 to severely toxic oxidation states), followed by decreased superoxide dismutase activity and massive reactive oxygen species (ROS) production. These effects occur selectively within cancer cells, causing mitochondrial damage, cell-cycle arrest, and DNA damage. Moreover, AsNDs@PEG when applied in a multi-drug combination strategy with beta-elemene, a plant-derived anticancer drug, achieves synergistic antitumor outcomes, and its newly discovered on-demand photothermal properties facilitate the elimination of the tumors without recurrence, potentially further expanding its clinical utility. In line of the practicability for a large-scale fabrication and negligible systemic toxicity of AsNDs@PEG (even at high doses and with repetitive administration), a new-concept arsenical drug with high therapeutic efficacy for selective solid tumor therapy is provided. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21715]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo 315201, Peoples R China. 2.Tao, W (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA. 3.Tao, W (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA. 4.Xie, T (corresponding author), Hangzhou Normal Univ, Sch Med, Coll Pharm, Hangzhou 311121, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Liu, Chuang,Sun, Shan,Feng, Qiang,et al. Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ss-Elemene for Cancer Therapy[J]. ADVANCED MATERIALS,2021,33(37). |
| APA | Liu, Chuang.,Sun, Shan.,Feng, Qiang.,Wu, Gongwei.,Wu, Yiting.,...&Tao, Wei.(2021).Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ss-Elemene for Cancer Therapy.ADVANCED MATERIALS,33(37). |
| MLA | Liu, Chuang,et al."Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ss-Elemene for Cancer Therapy".ADVANCED MATERIALS 33.37(2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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