Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells
文献类型：期刊论文
| 作者 | He, Meng; Lin, Jie; Akakuru, Ozioma Udochukwu; Xu, Xiawei; Li, Yanying; Cao, Yi; Xu, Yanping; Wu, Aiguo |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2021 |
| 关键词 | ENHANCED RAMAN-SCATTERING PHOTOINDUCED CHARGE-TRANSFER NANOSPHERES SENSITIVITY CAPTURE |
| 英文摘要 | The detection of circulating tumor cells (CTCs) is a crucial tool for early cancer diagnosis, prognosis, and postoperative evaluation. However, detection sensitivity remains a major challenge because CTCs are extremely rare in peripheral blood. To effectively detect CTCs, octahedral Ag2O nanoparticles (NPs) with high dispersibility, good biocompatibility, remarkable surface-enhanced Raman scattering (SERS) enhancement, and obvious enhancement selectivity are designed as an SERS platform. Ag2O NPs with many oxygen vacancy defects are successfully synthesized, which exhibit an ultra-high SERS enhancement factor (1.98x10(6)) for 4-mercaptopyridine molecules. The remarkable SERS activity of octahedral Ag2O NPs is derived from the synergistic effect of the surface defect-promoted photo-induced charge transfer (PICT) process and strong vibration coupling resonance in the Ag2O-molecule SERS complex, greatly amplifying the molecular Raman scattering cross-section. The promoted PICT process is confirmed using ultraviolet-visible (UV-Vis) absorption spectroscopy, demonstrating that obvious PICT resonance occurs in Ag2O SERS system under visible light. An additional growth step of SERS bioprobe is proposed by modifying the Raman signal molecules and functional biological molecules on Ag2O NPs for CTC detection. The Ag2O-based SERS bioprobe exhibits excellent detection specificity for different cancer cells in rabbit blood. Importantly, the high-sensitivity Ag2O-based SERS bioprobe satisfies the requirement for rare CTC detection in the peripheral blood of cancer patients, and the detection limit can reach 1 cell per mL. To our knowledge, this study is the first time that a semiconductor SERS substrate has been successfully utilized in CTC detection. This work provides new insights into CTC detection and the development of novel semiconductor-based SERS platforms for cancer diagnosis. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21754]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Lin, J 2.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, Ningbo 315201, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn Int Cooperat Base Biomed Ma, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | He, Meng,Lin, Jie,Akakuru, Ozioma Udochukwu,et al. Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells[J]. SCIENCE CHINA-LIFE SCIENCES,2021. |
| APA | He, Meng.,Lin, Jie.,Akakuru, Ozioma Udochukwu.,Xu, Xiawei.,Li, Yanying.,...&Wu, Aiguo.(2021).Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells.SCIENCE CHINA-LIFE SCIENCES. |
| MLA | He, Meng,et al."Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells".SCIENCE CHINA-LIFE SCIENCES (2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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