Ultrasound-Mediated Cavitation Enhances EGFR-Targeting PLGA-PEG Nano-Micelle Delivery for Triple-Negative Breast Cancer Treatment
文献类型：期刊论文
| 作者 | Chen, Libin; Zhang, Tao; Sun, Shan; Ren, Wenzhi; Wu, Aiguo; Xu, Huixiong |
| 刊名 | CANCERS
 |
| 出版日期 | 2021 |
| 卷号 | 13期号:14 |
| 关键词 | DOXORUBICIN CHALLENGES PEGYLATION THERAPY |
| 英文摘要 | Triple-negative breast cancer (TNBC) is highly recurring and metastatic breast cancer with overexpressing epidermal growth factor receptor (EGFR). Herein, a series of in vitro and in vivo analyses were used to explore the therapeutic effect of EGFR-targeting nano-micelles (PLGAPEG/DOX@anti-EGFR) combined with ultrasound-mediated cavitation (UMC). The prepared nanomicelle drug carriers have good biocompatibility and can greatly increase the drug accumulation in tumor regions, thereby reducing off-target toxicity while enhancing anti-tumor efficacy. Moreover, an in vivo analysis of the practical utility of this treatment modality was conducted by using SonoVueTM microbubbles to achieve cavitation under different power intensity levels, with an ultrasonic power intensity of 0.5 W/cm2 maximizing the intra-tumoral blood perfusion. Relative to PLGA-PEG@DOX/anti-EGFR nano-micelles treatment alone, the combination with UMC was better able to suppress tumor growth even at low concentrations. As such, combining actively targeted drug-carrier molecules with UMC represents an effective approach to enhancing therapeutic efficacy while reducing the adverse, systemic effects associated with DOX and other chemotherapeutic drugs, and it can be considered as a promising clinical prospect in the treatment of TNBC. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21775]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Xu, HX (corresponding author), Tongji Univ, Ctr Minimally Invas Treatment Tumor,Shanghai Engn, Dept Med Ultrasound,Clin Res Ctr Intervent Med,Sc, Shanghai Peoples Hosp 10,Ultrasound Res & Educ In, 301 Yanchangzhong Rd, Shanghai 200072, Peoples R China. 2.Xu, HX (corresponding author), Tongji Univ, Sch Med, Shanghai 200072, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn,Int Cooperat Base, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 4.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, Libin,Zhang, Tao,Sun, Shan,et al. Ultrasound-Mediated Cavitation Enhances EGFR-Targeting PLGA-PEG Nano-Micelle Delivery for Triple-Negative Breast Cancer Treatment[J]. CANCERS,2021,13(14). |
| APA | Chen, Libin,Zhang, Tao,Sun, Shan,Ren, Wenzhi,Wu, Aiguo,&Xu, Huixiong.(2021).Ultrasound-Mediated Cavitation Enhances EGFR-Targeting PLGA-PEG Nano-Micelle Delivery for Triple-Negative Breast Cancer Treatment.CANCERS,13(14). |
| MLA | Chen, Libin,et al."Ultrasound-Mediated Cavitation Enhances EGFR-Targeting PLGA-PEG Nano-Micelle Delivery for Triple-Negative Breast Cancer Treatment".CANCERS 13.14(2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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