ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy
文献类型：期刊论文
| 作者 | Zhang, Zhoujing; Liu, Chuang; Akakuru, Ozioma; Xu, Wenjing; Wu, Aiguo; Zhang, Yewei |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2021 |
| 卷号 | 37期号:4页码:967-974 |
| 关键词 | RECEPTOR-ALPHA TARGETED THERAPY NANOPARTICLES EXPRESSION DELIVERY CANCER |
| 英文摘要 | This research investigated a novel folic acid(FA)-modified zirconium core metal-organic framework(MOF) Uio-66 as a nanocarrier to deliver indocyanine green(ICG) and Sunitinib to cancer cells for combination therapy. Platinum-loaded Uio-66 nanoparticles(Pu) were synthesized via a one-pot method, followed by the modification with FA on their surfaces. This afforded FPu that enabled subsequent loading of ICG and Sunitinib to achieve dualmodal cancer therapy. Drug loading/release test and singlet oxygen detection were also conducted in vitro, and the nanoparticles showed considerable drug loading efficiency for both ICG and Sunitinib, coupled with a high singlet oxygen generation rate. Specifically, drug loading and encapsulation efficiency of Sunitinib were 2.30% and 72.67%, while those for ICG were 2.87% and 90.28%, respectively. Additionally, cytotoxicity test on HepG2 human hepatocellular carcinoma cancer cell line revealed that the fully functional nanoparticles possess excellent biocompatibility and as such could be further investigated as a potential drug delivery system for effectual carcinoma cancer treatment. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21811]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst BioMed Engn, CNITECH, Ningbo 315201, Peoples R China. 2.Zhang, YW (corresponding author), Southeast Univ, Sch Med, Nanjing 210009, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhang, Zhoujing,Liu, Chuang,Akakuru, Ozioma,et al. ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2021,37(4):967-974. |
| APA | Zhang, Zhoujing,Liu, Chuang,Akakuru, Ozioma,Xu, Wenjing,Wu, Aiguo,&Zhang, Yewei.(2021).ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,37(4),967-974. |
| MLA | Zhang, Zhoujing,et al."ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 37.4(2021):967-974. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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