Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan-Gelatin Hydrogel Composites for Tissue Engineering
文献类型：期刊论文
| 作者 | Osi, Amarachi Rosemary; Zhang, Hua; Chen, Jing; Zhou, Yang; Wang, Rong; Fu, Jun; Mueller-Buschbaum, Peter; Zhong, Qi |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2021 |
| 卷号 | 13期号:19页码:22902-22913 |
| 关键词 | PHOTOCROSSLINKABLE GELATIN SCAFFOLDS DESIGN TRENDS MATRIX |
| 英文摘要 | Biomimetic constructs imitating the functions, structures, and compositions of normal tissues are of great importance for tissue repair and regeneration. Three-dimensional (3D) printing is an innovative method to construct intricate biomimetic 3D tissue engineering scaffolds with spatiotemporal deposition of materials to control the intrinsic architectural organization and functional performance of the scaffold. However, due to the lack of bioinks with suitable printability, high structural integrity, and biological compatibility, producing constructs that mimic the anisotropic 3D extracellular environments remains a challenge. Here, we present a printable hydrogel ink based on methylacrylate-modified chitosan (ChMA) and gelatin (GelMA) embedding nanohydroxyapatite (nano-Hap). This polymer composite is first physically cross-linked by thermal gelation for postprinting structural stability, followed by covalent photo-cross-linking of ChMA and GelMA to form a long-term stable structure. The rheological behavior of the hydrogels and the mechanical strengths of the printed constructs are tuned by adjusting the content of GelMA, which in turn enhances the shape retention after printing and enables the precise deposition of multilayered 3D scaffolds. Moreover, the formulated biomaterial inks exhibit biological characteristics that effectively support the spreading and proliferation of stem cells seeded on the scaffolds after 7 days of in vitro culture. Adding Hap has minor influences on the mechanical rigidity and cytocompatibility of the hydrogels compared with the group free of Hap. Together, the printable biomaterial inks with shear thinning and good structural integrity, along with biological cues, are promising for tissue engineering application. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21912]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | Fu, J (corresponding author), Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Osi, Amarachi Rosemary,Zhang, Hua,Chen, Jing,et al. Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan-Gelatin Hydrogel Composites for Tissue Engineering[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(19):22902-22913. |
| APA | Osi, Amarachi Rosemary.,Zhang, Hua.,Chen, Jing.,Zhou, Yang.,Wang, Rong.,...&Zhong, Qi.(2021).Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan-Gelatin Hydrogel Composites for Tissue Engineering.ACS APPLIED MATERIALS & INTERFACES,13(19),22902-22913. |
| MLA | Osi, Amarachi Rosemary,et al."Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan-Gelatin Hydrogel Composites for Tissue Engineering".ACS APPLIED MATERIALS & INTERFACES 13.19(2021):22902-22913. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。