Targeted perfusion adsorption for hyperphosphatemia using mixed matrix microspheres (MMMs) encapsulated NH2-MIL-101(Fe)
文献类型：期刊论文
| 作者 | Chen, Wenhui; Han, Qiu; Liu, Yang; Wang, Yiwen; Liu, Fu |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2021 |
| 卷号 | 9期号:22页码:4555-4566 |
| 关键词 | METAL-ORGANIC FRAMEWORKS CHRONIC KIDNEY-DISEASE SEVELAMER CARBONATE PREDIALYSIS PATIENTS PHOSPHATE BINDERS CROSSOVER DESIGN SERUM ANTICOAGULANT LANTHANUM EFFICACY |
| 英文摘要 | Hyperphosphatemia, a common complication of chronic renal failure patients, is described as an excess amount of serum phosphate >4.5 mg dL(-1). Current therapy for hyperphosphatemia is limited by low removal efficiency, secondary hyperparathyroidism, uremic bone disease, and the promotion of vascular and visceral calcifications. Metal organic frameworks (MOFs) have aroused great interest in the field of blood purification because of their strong specific adsorption. Herein, we prepared mixed matrix microspheres (MMMs) encapsulated NH2-MIL-101(Fe) with specific adsorption to blood phosphate. Simultaneously, a heparinoid copolymer poly (acrylic acid-sodium 4-vinylbenzenssulfonate) (P(AA-SSNa)) was incorporated to improve the hemocompatibility. The proposed MMMs exhibited excellent phosphate adsorption capacity both in aqueous and human plasma environments. They also showed comprehensive hemocompatibility e.g. low tendency of protein adsorption, low hemolysis rate and extended blood coagulation time. In general, we envision that the MMMs are potentially suitable as highly efficient hemoperfusion adsorbents for hyperphosphatemia treatment. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21934]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Liu, F (corresponding author), Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China. 2.Liu, F (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Key Lab Marine Mat & Protect Technol, Key Lab Marine Mat & Related Technol, 1219 Zhongguan West Rd, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, Wenhui,Han, Qiu,Liu, Yang,et al. Targeted perfusion adsorption for hyperphosphatemia using mixed matrix microspheres (MMMs) encapsulated NH2-MIL-101(Fe)[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(22):4555-4566. |
| APA | Chen, Wenhui,Han, Qiu,Liu, Yang,Wang, Yiwen,&Liu, Fu.(2021).Targeted perfusion adsorption for hyperphosphatemia using mixed matrix microspheres (MMMs) encapsulated NH2-MIL-101(Fe).JOURNAL OF MATERIALS CHEMISTRY B,9(22),4555-4566. |
| MLA | Chen, Wenhui,et al."Targeted perfusion adsorption for hyperphosphatemia using mixed matrix microspheres (MMMs) encapsulated NH2-MIL-101(Fe)".JOURNAL OF MATERIALS CHEMISTRY B 9.22(2021):4555-4566. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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