H2O2-Responsive Gold Nanoclusters @ Mesoporous Silica @ Manganese Dioxide Nanozyme for Off/On Modulation and Enhancement of Magnetic Resonance Imaging and Photodynamic Therapy
文献类型：期刊论文
| 作者 | Yin, Zhibin; Ji, Qian; Wu, Di; Li, Ziwei; Fan, Minfei; Zhang, Hongxin; Zhao, Xiaolong; Wu, Aiguo; Cheng, Liang; Zeng, Leyong |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2021 |
| 卷号 | 13期号:13页码:14928-14937 |
| 关键词 | NANOPARTICLES DESIGN CANCER OXYGEN |
| 英文摘要 | In order to achieve safe and high-efficient photodynamic therapy (PDT), it was a powerful strategy of constructing O-2-generated nanozyme with intelligent off/on modulation and enhancement. Herein, a kind of H2O2-responsive nanozyme was developed for off/on modulation and enhancement of magnetic resonance (MR) imaging and PDT, in which great amounts of gold nanoclusters (AuNCs) were loaded into mesoporous silica to form nanoassembly, and manganese dioxide (MnO2) nanosheets were wrapped as switching shield shell (AuNCs@mSiO(2)@MnO2). In a neutral physiological environment, stable MnO2 shells eliminated singlet oxygen (O-1(2)) generation to switch off PDT and MR imaging. However, in an acidic tumor microenvironment, the MnO2 shell reacted with H2O2, in which MnO2 degradation switched on MR imaging and PDT, and the generated O-2 further enhanced PDT. H2O2-responsive MnO2 degradation brought about excellent MR imaging with a longitudinal relaxation rate of 25.31 mM(-1) s(-1), and simultaneously sufficient O-2 generation guaranteed a 74% high O-1(2) yield. Under the irradiation of a 635 nm laser, the viability of MDA-MB-435 cells was reduced to 4%, and the tumors completely disappeared, demonstrating strong PDT performance. Therefore, H2O2-responsive AuNCs@mSiO(2)@MnO2 nanozyme showed excellent off/on modulation and enhancement of MR imaging and PDT and was a promising intelligent nanoprobe for safe and high-efficiency theranostics. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22034]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. 2.Cheng, L (corresponding author), Soochow Univ, Inst Funct Nano & Soft Mat, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China. 3.Zeng, LY (corresponding author), Hebei Univ, Coll Chem & Environm Sci, Inst Life Sci & Green Dev, Key Lab Med Chem & Mol Diag,Minist Educ,Chem Biol, Baoding 071002, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Yin, Zhibin,Ji, Qian,Wu, Di,et al. H2O2-Responsive Gold Nanoclusters @ Mesoporous Silica @ Manganese Dioxide Nanozyme for Off/On Modulation and Enhancement of Magnetic Resonance Imaging and Photodynamic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(13):14928-14937. |
| APA | Yin, Zhibin.,Ji, Qian.,Wu, Di.,Li, Ziwei.,Fan, Minfei.,...&Zeng, Leyong.(2021).H2O2-Responsive Gold Nanoclusters @ Mesoporous Silica @ Manganese Dioxide Nanozyme for Off/On Modulation and Enhancement of Magnetic Resonance Imaging and Photodynamic Therapy.ACS APPLIED MATERIALS & INTERFACES,13(13),14928-14937. |
| MLA | Yin, Zhibin,et al."H2O2-Responsive Gold Nanoclusters @ Mesoporous Silica @ Manganese Dioxide Nanozyme for Off/On Modulation and Enhancement of Magnetic Resonance Imaging and Photodynamic Therapy".ACS APPLIED MATERIALS & INTERFACES 13.13(2021):14928-14937. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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