Reinforcing and discriminative-stimulus effects of two pyrrolidine-containing synthetic cathinone derivatives in rats
文献类型：期刊论文
| 作者 | Xu, Peng; Lai, Miaojun; Fu, Dan; Liu, Huifen; Wang, Youmei; Shen, Haowei; Zhou, Wenhua |
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
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| 出版日期 | 2021 |
| 卷号 | 203 |
| 英文摘要 | The molecular and behavioral aspects of alpha-pyrrolidinopentiophenone (alpha-PVP) have been characterized; however, how the structural modification of alpha-PVP affects its abuse potential is still unknown. In this study, we investigated the abuse potential of two pyrrolidinylated second-generation cathinones:4-chloro-alpha-pyrrolidinopentiophenone (4cl-alpha-PVP) and 4-chloro-alpha-pyrrolidinopropiophenone (4cl-alpha-PPP). Male Sprague-Dawley rats were trained to self-administer methamphetamine (METH, 0.05 mg.kg(-1).infusion(-1)), alpha-PVP (0.05 mg.kg(-1).infusion(-1)), 4cl-alpha-PVP (0.05 mg.kg(-1).infusion(-1)), and 4cl-alpha-PPP (0.5 mg.kg(-1).infusion(-1)) under a fixed ratio (FR)(-1) reinforcement schedule for-10 sessions. The discriminative-stimulus effect of METH (0.8 mg/kg) from saline was tested under an FR10 schedule of food delivery. alpha-PVP, 4cl-alpha-PVP and 4cl-alpha-PPP produced reinforcement behaviors and presented an inverted U-shaped dose effect. The reinforcing potency was displayed with a rank order of alpha-PVP (0.029 mg.kg(-1).infusion(-1)) > METH (0.040 mg.kg(-1).infusion(-1)) > 4cl-alpha-PVP (0.094 mg.kg(-1).infusion(-1)) > 4cl-alpha-PPP (0.51 mg.kg(-1).infusion(-1)). All three drugs were fully substituted for the discriminative-stimulus effects of METH in rats. The substitution potency for discriminative-stimulus effects of alpha-PVP (ED50 = 0.4 mg/kg) was approximately equal to that of METH (ED50 = 0.3 mg/kg), while the discriminative potency of 4cl-alpha-PVP (ED50 =-1.0 mg/kg) and 4cl-alpha-PPP (ED50 = 5 mg/kg) was approximately 3 and-16-fold less than that of METH. The rank order of potency was alpha-PVP approximate to METH > 4cl-alpha-PVP > 4cl-alpha-PPP. The present data demonstrated that 4cl-alpha-PVP and 4cl-alpha-PPP produced reinforcing effects and fully and dose-dependently substituted for the subjective effects of METH, suggesting that both 4cl-alpha-PVP and 4cl-alpha-PPP have abuse potential that may be similar to METH. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22060]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Shen, HW (corresponding author), Ningbo Univ, Fac Physiol & Pharmacol, Sch Med, Ningbo 315211, Zhejiang, Peoples R China. 2.Zhou, WH (corresponding author), Ningbo Univ, Ningbo Kangning Hosp, Sch Med, Zhejiang Prov Key Lab Addict, Ningbo 315201, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Xu, Peng,Lai, Miaojun,Fu, Dan,et al. Reinforcing and discriminative-stimulus effects of two pyrrolidine-containing synthetic cathinone derivatives in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2021,203. |
| APA | Xu, Peng.,Lai, Miaojun.,Fu, Dan.,Liu, Huifen.,Wang, Youmei.,...&Zhou, Wenhua.(2021).Reinforcing and discriminative-stimulus effects of two pyrrolidine-containing synthetic cathinone derivatives in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,203. |
| MLA | Xu, Peng,et al."Reinforcing and discriminative-stimulus effects of two pyrrolidine-containing synthetic cathinone derivatives in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 203(2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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