Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease
文献类型：期刊论文
| 作者 | Enwereuzo, Onyekachi Oluchi; Akakuru, Obinna Chigoziem; Uwaoma, Romanus Chinonso; Elemike, Elias Emeka; Akakuru, Ozioma Udochukwu |
| 刊名 | JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 11期号:4页码:707-719 |
| 英文摘要 | Controlled release technology has continuously attracted attention as a strategy to deliver active agents to specific internal body regions with attendant cost-effectiveness among other intriguing merits. Here, drug-loaded nanoparticles (NPs) are synthesized for ultimate application in the treatment of gastroesophageal reflux disease (GERD), leveraging the benefits of controlled release strategy. To achieve this, eggshell membranes (ESMs) were extracted and combined with chitosan (CHS) to rationally obtain self-assembled CHS-ESM NPs that served as a novel nanocarrier to effectively compartmentalize a GERD-therapeutic drug famotidine (FTD) and form self-assembled FTD@CHS-ESM NPs. Advantageously, the proof-of-concept FTD@CHS-ESM NPs offer superlative tissue tolerance. The cumulative FTD release is 89% after 12 h at pH 1.2, suggesting the capability of FTD@CHS-ESM NPs for effectual controlled drug release; a testimonial of the effective compartmentalization of FTD in the nanocarrier. Furthermore, the release of FTD from the FTD@CHS-ESM NPs is best described by Higuchi square root model, in a non-Fickian diffusional release mechanism (n = 0.584 and 0.582 in pH 1.2 and pH 6.8, respectively). The drug release system demonstrated in this work, therefore, holds strong promise for the oral nanomedical treatment of GERD in vivo, and promotes the rational synthesis of organic-based biocompatible nanomaterials for biomedical application. [GRAPHICS] . |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22119]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Akakuru, OU (corresponding author), Univ Calabar, Dept Pure & Appl Chem, Calabar, Nigeria. 2.Akakuru, OU (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Enwereuzo, Onyekachi Oluchi,Akakuru, Obinna Chigoziem,Uwaoma, Romanus Chinonso,et al. Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease[J]. JOURNAL OF NANOSTRUCTURE IN CHEMISTRY,2021,11(4):707-719. |
| APA | Enwereuzo, Onyekachi Oluchi,Akakuru, Obinna Chigoziem,Uwaoma, Romanus Chinonso,Elemike, Elias Emeka,&Akakuru, Ozioma Udochukwu.(2021).Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease.JOURNAL OF NANOSTRUCTURE IN CHEMISTRY,11(4),707-719. |
| MLA | Enwereuzo, Onyekachi Oluchi,et al."Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease".JOURNAL OF NANOSTRUCTURE IN CHEMISTRY 11.4(2021):707-719. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。