Inhibition of PLC beta 1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats
文献类型：期刊论文
| 作者 | Xu, Xing; Fan, Runyue; Ruan, Yanqian; Xu, Mengjie; He, Jiajie; Cao, Mengye; Li, Xingxing; Zhou, Wenhua; Liu, Yu |
| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 149 |
| 英文摘要 | Studies have shown that the central renin-angiotensin system is involved in neurological disorders. Our previous studies have demonstrated that angiotensin II receptor type 1 (AT1R) in the brain could be a potential target against methamphetamine (METH) use disorder. The present study was designed to investigate the underlying mechanisms of the inhibitory effect of AT1R on various behavioural effects of METH. We first examined the effect of AT1R antagonist, candesartan cilexetil (CAN), on behavioural and neurotoxic effects of METH. Furthermore, we studied the role of phospholipase C beta 1 (PLC beta 1) blockade behavioural and neurotoxic effects of METH. The results showed that CAN significantly attenuated METH-induced behavioral disorders and neurotoxicity associated with increased oxidative stress. AT1R and PLC beta 1 were significantly upregulated in vivo and in vitro. Inhibition of PLC beta 1 effectively alleviated METH-induced neurotoxicity and METH self-administration (SA) by central blockade of the PLC beta 1 involved signalling pathway. PLC beta 1 blockade significantly decreased the reinforcing and motivation effects of METH. PLC beta 1 involved signalling pathway, as well as a more specific role of PLC beta 1, involved the inhibitory effects of CAN on METH-induced behavioural dysfunction and neurotoxicity. Collectively, our findings reveal a novel role of PLC beta 1 in METH-induced neurotoxicity and METH use disorder. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22135]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Xu, X (corresponding author), Ningbo Univ, Affiliated Hosp, Med Sch, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China. 2.Xu, X 3.Liu, Y (corresponding author), Ningbo Univ, Sch Med, Dept Physiol & Pharmacol, Ningbo 315211, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Xu, Xing,Fan, Runyue,Ruan, Yanqian,et al. Inhibition of PLC beta 1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2021,149. |
| APA | Xu, Xing.,Fan, Runyue.,Ruan, Yanqian.,Xu, Mengjie.,He, Jiajie.,...&Liu, Yu.(2021).Inhibition of PLC beta 1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats.FOOD AND CHEMICAL TOXICOLOGY,149. |
| MLA | Xu, Xing,et al."Inhibition of PLC beta 1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats".FOOD AND CHEMICAL TOXICOLOGY 149(2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。