Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo
文献类型：期刊论文
| 作者 | Jiang, Zhenqi; Li, Yanying; Wei, Zhenni; Yuan, Bo; Wang, Yinjie; Akakuru, Ozioma Udochukwu; Li, Yong; Li, Juan; Wu, Aiguo |
| 刊名 | BIOACTIVE MATERIALS
 |
| 出版日期 | 2021 |
| 卷号 | 6期号:3页码:740-748 |
| 关键词 | METAL-ORGANIC-FRAMEWORK FAVORABLE BIOCOMPATIBILITY ZIF-8 MEMBRANE LIQUID |
| 英文摘要 | Zeolitic Imidazole Frameworks (ZIFs) are widely applied in nanomedicine for their high drug loading, suitable pore size, pH-responsive drug release, and so on. However, fast drug release during circulation, unexpected toxicity to mice major organs, undesirable long-term accumulation in the lung and even death currently hinder their in vivo biomedical applications. Herein, we report an amorphous ZIF-8 (aZIF-8) with high loading of 5-Fu through pressure-induced amorphization. This nano-system avoids early drug release during circulation and provides tumor microenvironment-responsive drug release with improved in vitro cell viability, and survival rate in in vivo evaluations as compared to ZIF-8. Furthermore, aZIF-8 shows longer blood circulation and lower lung accumulation than ZIF-8 at same injected doses. Less drug release during circulation, longer blood circulation, and better biocompatibility of aZIF-8/5-Fu significantly improves its therapeutic efficacy in ECA-109 tumor-bearing mouse, and result in 100% survival rate over 50 days after treatment. Therefore, aZIF-8 with favorable biocompatibility and long blood circulation is expected to be a promising nano-system for efficacious cancer therapy in vivo. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22154]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices,Key Lab Addit Mf, Ningbo 315201, Peoples R China. 2.Li, J |
| 推荐引用方式 GB/T 7714 | Jiang, Zhenqi,Li, Yanying,Wei, Zhenni,et al. Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo[J]. BIOACTIVE MATERIALS,2021,6(3):740-748. |
| APA | Jiang, Zhenqi.,Li, Yanying.,Wei, Zhenni.,Yuan, Bo.,Wang, Yinjie.,...&Wu, Aiguo.(2021).Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo.BIOACTIVE MATERIALS,6(3),740-748. |
| MLA | Jiang, Zhenqi,et al."Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo".BIOACTIVE MATERIALS 6.3(2021):740-748. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。